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000283104 037__ $$aDZNE-2025-01511
000283104 041__ $$aEnglish
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000283104 1001_ $$0P:(DE-2719)9002873$$aGoa, Pal Erik$$b0$$udzne
000283104 245__ $$aBrain Pulsation Imaging Using Non-Balanced Steady-State Free Precession With 3D-EPI Readout.
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000283104 520__ $$aTo present a new, fast MR imaging method for visualization and quantification of pulsatile displacement in brain tissue and fluid.The natural phase-contrast of non-balanced steady-state free precession combined with careful tuning of the intrinsic spoiler gradients is harnessed to measure displacement along specific physical directions. Efficient segmented 3D-EPI allows for whole brain coverage within TR = 0.15 s. Motion sensitive terms are added to the extended phase graph theory and simulations are used to optimize the sequence parameters and to calibrate the phase sensitivity. Pilot data on 4 healthy volunteers are acquired at 7T and analyzed after cardiac retrogating. A set of three 1-min scans with spoiler gradients along orthogonal axes is required to estimate full 3D displacement vectors.Simulations show that pulsatile displacements up to around 1 mm can be resolved with the proposed method. In vivo example data are in general agreement with predictions from simulations. The precision of the displacement measurements is estimated to be 0.01 mm using repeated scans of the same subject, and while estimated displacement values agree well with literature values for example tissue ROIs, the measurement accuracy needs to be further explored. The method provides a detailed view of the pulsatile motion along all three physical axes and with full 3D coverage of the brain.Brain Pulsation Imaging allows for quantitative measurements of displacement vectors through the cardiac cycle with whole brain coverage within 3-5 min. The method is robust and should have significant potential for clinical application.
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000283104 650_7 $$2Other$$a3D‐EPI
000283104 650_7 $$2Other$$aCSF
000283104 650_7 $$2Other$$aEPI
000283104 650_7 $$2Other$$aSSFP
000283104 650_7 $$2Other$$aUHF‐MRI
000283104 650_7 $$2Other$$abrain
000283104 650_7 $$2Other$$anbSSFP
000283104 650_7 $$2Other$$aneuroimaging
000283104 650_7 $$2Other$$anon‐balanced
000283104 650_7 $$2Other$$apulsation
000283104 650_2 $$2MeSH$$aHumans
000283104 650_2 $$2MeSH$$aBrain: diagnostic imaging
000283104 650_2 $$2MeSH$$aBrain: physiology
000283104 650_2 $$2MeSH$$aBrain: anatomy & histology
000283104 650_2 $$2MeSH$$aImaging, Three-Dimensional: methods
000283104 650_2 $$2MeSH$$aEcho-Planar Imaging: methods
000283104 650_2 $$2MeSH$$aAlgorithms
000283104 650_2 $$2MeSH$$aComputer Simulation
000283104 650_2 $$2MeSH$$aAdult
000283104 650_2 $$2MeSH$$aMale
000283104 650_2 $$2MeSH$$aMotion
000283104 650_2 $$2MeSH$$aReproducibility of Results
000283104 7001_ $$0P:(DE-2719)9001302$$aBlömer, Simon$$b1
000283104 7001_ $$0P:(DE-2719)2810697$$aStirnberg, Rüdiger$$b2
000283104 7001_ $$0P:(DE-2719)2810538$$aStöcker, Tony$$b3$$eLast author
000283104 773__ $$0PERI:(DE-600)1493786-4$$a10.1002/mrm.70156$$gVol. 95, no. 3, p. 1606 - 1618$$n3$$p1606 - 1618$$tMagnetic resonance in medicine$$v95$$x1522-2594$$y2026
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