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@INPROCEEDINGS{Gerards:283111,
      author       = {Gerards, Michelle and Hübner, Constanze and Baumeister,
                      Annika and Ribaldi, Federica and Cantero-Fortiz, Yahveth and
                      Braun, Julia and Boada, Mercè and Frisoni, Giovanni B and
                      Schmitz-Luhn, Björn and Schwegler, Carolin and Woopen,
                      Christiane and Jessen, Frank and Rostamzadeh, Ayda},
      title        = {{T}he {R}ole of {R}isk {P}erception and {P}sychosocial
                      {F}actors in {A}ttitudes and {V}iews on {P}reclinical
                      {D}ementia {R}isk {E}stimation – {T}he
                      {P}re{TAD}‐{S}tudy},
      journal      = {Alzheimer's and dementia},
      volume       = {21},
      number       = {S3},
      issn         = {1552-5260},
      reportid     = {DZNE-2026-00007},
      pages        = {e098147},
      year         = {2025},
      abstract     = {Background:Advances in disease-modifying treatments and
                      blood-based biomarkers for Alzheimer's disease (AD) have
                      increased the importance of early diagnosis and dementia
                      risk estimation before symptom onset. Autonomous decisions
                      about AD risk estimation are complex and should align with
                      individual needs and preferences. The PreTAD study
                      (Predictive Turn in Alzheimer's Disease: Ethical, Clinical,
                      Linguistic, and Legal Aspects) evaluates and compares
                      attitudes on dementia risk estimation among first-degree
                      relatives of individuals with dementia and patients with
                      subjective cognitive decline to improve counseling for
                      preclinical predictive AD diagnostics in the
                      future.Method:PreTAD assesses risk perception, attitudes and
                      views on AD dementia risk estimation, along with influencing
                      psychosocial factors (living situation, loneliness,
                      resilience, anxiety, and depression). The risk perception
                      survey assessed participants’ opinions on two aspects: (1)
                      what percentage they consider to represent a high general
                      risk of developing AD dementia (perceived high general
                      dementia risk), and (2) their perceived personal risk of
                      developing AD dementia within 10 years (personal dementia
                      risk).Result:Results from 390 participants in Germany,
                      Switzerland, and Spain are presented. The perceived high
                      general dementia risk assessed by participants ranged from
                      $>0\%-100\%.$ Around $30\%$ perceived their personal
                      dementia risk as $0–10\%,$ while $70\%$ rated their
                      personal dementia risk as higher than $10\%.$ Higher
                      estimated personal dementia risk was associated with a
                      greater estimated impact of biomarker-based early dementia
                      risk estimation and clinical trial participation on the
                      decision to estimate one's own dementia risk. Perceived high
                      general dementia risk correlated with a higher influence of
                      income, belief in the impact of lifestyle changes, and
                      preference for high test accuracy over low invasiveness on
                      the decision to estimate dementia risk. Higher perceived
                      personal dementia risk correlated with lower resilience and
                      higher anxiety.Conclusion:Risk perception is highly
                      individual and may influence the process of AD dementia risk
                      estimation. While psychosocial factors appear to have a
                      limited impact on the decision to pursue dementia risk
                      estimation in a hypothetical scenario, their impact in the
                      subsequent process remains unclear. PreTAD findings
                      highlight the need for personalized counseling that
                      considers emotional and cognitive profiles to support
                      informed decision-making in preclinical predictive AD
                      diagnostics.},
      month         = {Jul},
      date          = {2025-07-27},
      organization  = {Alzheimer’s Association
                       International Conference, Toronto
                       (Canada), 27 Jul 2025 - 31 Jul 2025},
      cin          = {AG Jessen},
      ddc          = {610},
      cid          = {I:(DE-2719)1011102},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)1 / PUB:(DE-HGF)16},
      doi          = {10.1002/alz70857_098147},
      url          = {https://pub.dzne.de/record/283111},
}