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@INPROCEEDINGS{Zhunussova:283112,
      author       = {Zhunussova, Alina and Loane, Clare and Kurt, Elif and
                      Femminella, Grazia Daniela and Lenzoni, Sabrina and Duckett,
                      Millie and Callaghan, Martina F and Weiskopf, Nikolaus and
                      Dolan, Raymond J and Howard, Robert and Düzel, Emrah and
                      Hämmerer, Dorothea},
      title        = {{C}hanges in {T}ask‐evoked {P}upil {D}ilation during
                      {E}motional {M}emory as a {M}arker of {N}oradrenergic
                      {F}unction in {H}ealthy {A}ging and {MCI}},
      journal      = {Alzheimer's and dementia},
      volume       = {21},
      number       = {S7},
      issn         = {1552-5260},
      reportid     = {DZNE-2026-00008},
      pages        = {e108410},
      year         = {2025},
      abstract     = {Background:Improved memory for negative events is supported
                      by the locus coeruleus-noradrenergic (LC-NA) system. As the
                      LC is one of the first structures exhibiting tau pathologies
                      in AD, in vivo markers for structural and functional changes
                      in the LC are required. We used pupil dilation (PD) as a
                      non-exclusive and indirect but easy and non-invasive way to
                      acquire a measure of LC-NA activity. We investigated whether
                      PD can serve as a marker of alteration in noradrenergic
                      function in mild cognitive impairment (MCI) during emotional
                      memory.Method:The emotional memory task was completed by 83
                      participants (28 younger adults (YAs), 25 older adults
                      (OAs), and 30 patients with MCI) during eye-tracking
                      recordings. In the incidental encoding task, participants
                      were shown a neutral or negative indoor or outdoor scene and
                      were instructed to categorize it as either indoor or
                      outdoor. In the immediate recognition test and the delayed
                      recognition test (6 hours later), participants were
                      instructed to classify the pictures as new or old.Result:PD
                      was larger for emotional as compared to neutral scenes in
                      YAs and OAs but overall increased in MCI patients,
                      regardless of scene type, suggesting a deficiency in
                      emotional regulation. The increase in emotional reactivity
                      in MCI does not translate into improved emotional memory; as
                      expected, emotional scenes were better remembered than
                      neutral scenes, with MCI patients showing worse memory than
                      YAs or OAs.Conclusion:PD can be reliably measured in
                      patients with MCI. Moreover, changes in task-evoked PD
                      during an emotional memory task can reveal differences
                      between healthy aging and MCI in emotional reactivity.},
      month         = {Jul},
      date          = {2025-07-27},
      organization  = {Alzheimer’s Association
                       International Conference, Toronto
                       (Canada), 27 Jul 2025 - 31 Jul 2025},
      cin          = {AG Düzel},
      ddc          = {610},
      cid          = {I:(DE-2719)5000006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)1 / PUB:(DE-HGF)16},
      doi          = {10.1002/alz70861_108410},
      url          = {https://pub.dzne.de/record/283112},
}