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@INPROCEEDINGS{Iliopoulos:283115,
      author       = {Iliopoulos, Panagiotis and Gellersen, Helena M. and Rong,
                      Boyan and Cichy, Radoslaw Martin and Maass, Anne and Düzel,
                      Emrah},
      title        = {{C}ognitive training–related volumetric changes in the
                      {A}36 perirhinal area are associated with mnemonic
                      discrimination gains in older adults: a 7{T} {MRI} study},
      journal      = {Alzheimer's and dementia},
      volume       = {21},
      number       = {S7},
      issn         = {1552-5260},
      reportid     = {DZNE-2026-00011},
      pages        = {e108566},
      year         = {2025},
      abstract     = {Background:Mnemonic discrimination (MD), the ability to
                      distinguish between similar but distinct memories, relies
                      heavily on the integrity of key medial temporal lobe (MTL)
                      regions. Aging is associated with declines in MD, but
                      evidence suggests that cognitive training may help mitigate
                      this decline. While prior research has shown that such
                      training can improve MD performance, little is known about
                      the relationship between these behavioral improvements and
                      structural changes in specific brain regions. This study
                      investigates whether an 8-week web-based MD training program
                      enhances MD in older adults and examines whether these gains
                      are linked to volumetric changes in MTL areas, including the
                      A36 perirhinal area, a critical region for object and scene
                      memory.Method:A total of 151 older adults (age M = 69.71
                      years, SD = 4.17) participated in an 8-week web-based MD
                      training program. Participants were divided into three
                      groups: object stimuli training (OG), scene stimuli training
                      (SG), and an active control group (AC). A subset of OG (n =
                      33) and AC (n = 28) participants underwent pre- and
                      post-training 7T MRI scans (MP2RAGE 0.6 mm; T2w imaging: 0.4
                      x 0.4 x 1 mm along the hippocampal axis). The training
                      required participants to differentiate between similar
                      objects and scenes ('lures') and repeated items
                      ('repeats’) in a progressively challenging MD task. Pre-
                      and post-training, participants completed a behavioral
                      battery assessing MD and cognitive transfer effects.
                      Volumetric changes in key MTL subregions, including the A36
                      perirhinal area, were assessed using the T2w ASHS algorithm
                      for the MTL areas’ segmentations.Result:Behavioral results
                      showed significant gains in MD in the OG and SG groups
                      compared to the control group. Notably, within the object
                      training but not the control group, volumetric increases in
                      the left A36 perirhinal area were specifically linked to MD
                      performance gains for scenes (ie. near transfer to scenes)
                      but not objects. This suggests a robust link between
                      structural plasticity and MD behavioral
                      improvement.Conclusion:Our findings indicate that an 8-week
                      MD training program enhances memory performance in older
                      adults and induces structural changes in the A36 perirhinal
                      area, highlighting the potential for cognitive training to
                      support brain health during aging.},
      month         = {Jul},
      date          = {2025-07-27},
      organization  = {Alzheimer’s Association
                       International Conference, Toronto
                       (Canada), 27 Jul 2025 - 31 Jul 2025},
      cin          = {AG Düzel / AG Maaß / AG Berron},
      ddc          = {610},
      cid          = {I:(DE-2719)5000006 / I:(DE-2719)1311001 /
                      I:(DE-2719)5000070},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)1 / PUB:(DE-HGF)16},
      doi          = {10.1002/alz70861_108566},
      url          = {https://pub.dzne.de/record/283115},
}