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| Home > Publications Database > The diagnostic value of transcranial sonography in Swedish parkinsonism patients: A retrospective cohort study with long-term follow-up. > print |
| Home > Publications Database > The diagnostic value of transcranial sonography in Swedish parkinsonism patients: A retrospective cohort study with long-term follow-up. > print |
| 001 | 283119 | ||
| 005 | 20260103103704.0 | ||
| 024 | 7 | _ | |a 10.1016/j.prdoa.2025.100411 |2 doi |
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| 100 | 1 | _ | |a Stiehm, M. |b 0 |
| 245 | _ | _ | |a The diagnostic value of transcranial sonography in Swedish parkinsonism patients: A retrospective cohort study with long-term follow-up. |
| 260 | _ | _ | |a Amsterdam |c 2025 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Although transcranial sonography (TCS) assessing hyperechogenic substantia nigra (SN+) as biomarker for Parkinsońs disease (PD) has been introduced elsewhere, the clinical relevance and accuracy in a Swedish population is still unknown.This retrospective single-center study included 74 patients with predominantly early-stage parkinsonism at first visit who had been examined by TCS from 2013 to 2017 to determine the SN+ biomarker status in relation to PD, atypical parkinsonian disorders (APS), essential tremor (ET) and vascular/secondary/ unspecified parkinsonism, with the aim of long-term follow-up to confirm the clinical diagnosis. The cut-off value for SN+ was regarded as the 90 % percentile of SN echogenicity in a local healthy cohort (here, 0.23 cm2).In 2024, the mean follow-up time was 95 months. Three patients (4 %) without transcranial bone were excluded. SN+ was found in 38/51 patients with finally diagnosed PD and 4/20 patients with other final clinical diagnoses (p < 0.001). Sensitivity was moderate (75 %) whereas specificity and the positive predictive value were higher (80 % and 90 %, respectively). SN area measurements (most abnormal side) were significantly different in PD-patients compared to non-PD patients (n = 63; 0.28 ± 0.09 [95 % CI: 0.25-0.30] cm2 vs. 0.23 ± 0.10 [0.18-0.29] cm2, p 0.035).After a follow-up of up to 8 years, to maximize diagnostic certainty, our findings support the use of TCS as a valuable add-on tool in PD diagnostics in a Swedish patient population, already in the early stage of disease but not for screening. |
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| 650 | _ | 7 | |a Essential tremor |2 Other |
| 650 | _ | 7 | |a Hyperechogenicity |2 Other |
| 650 | _ | 7 | |a Movement disorders |2 Other |
| 650 | _ | 7 | |a Parkinsonism |2 Other |
| 650 | _ | 7 | |a Parkinsońs disease |2 Other |
| 650 | _ | 7 | |a Substantia nigra |2 Other |
| 650 | _ | 7 | |a Transcranial sonography |2 Other |
| 650 | _ | 7 | |a Ultrasound |2 Other |
| 700 | 1 | _ | |a Nilsson, C. |b 1 |
| 700 | 1 | _ | |a Skogar, Ö |b 2 |
| 700 | 1 | _ | |a Walter, U. |0 P:(DE-2719)9000336 |b 3 |e Last author |u dzne |
| 773 | _ | _ | |a 10.1016/j.prdoa.2025.100411 |g Vol. 13, p. 100411 - |0 PERI:(DE-600)3003034-1 |p 100411 |t Clinical parkinsonism & related disorders |v 13 |y 2025 |x 2590-1125 |
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