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@INBOOK{CampiSantos:283120,
      author       = {Campi Santos, Patricia},
      title        = {{D}irect {I}noculation of {P}athogenic {Y}easts into
                      {M}ouse {L}ung by {T}rans-tracheal {I}nstillation.},
      volume       = {2993},
      address      = {New York, NY},
      publisher    = {Springer US},
      reportid     = {DZNE-2026-00016},
      isbn         = {978-1-0716-5018-9 (print)},
      series       = {Methods in Molecular Biology},
      pages        = {29 - 42},
      year         = {2026},
      comment      = {Models in Inflammation and Immunopharmacology / Secchim
                      Ribeiro, Lucas (Editor) ; New York, NY : Springer US, 2026,
                      Chapter 3 ; ISSN: 1064-3745=1940-6029 ; ISBN:
                      978-1-0716-5018-9=978-1-0716-5019-6 ;
                      doi:10.1007/978-1-0716-5019-6},
      booktitle     = {Models in Inflammation and
                       Immunopharmacology / Secchim Ribeiro,
                       Lucas (Editor) ; New York, NY :
                       Springer US, 2026, Chapter 3 ; ISSN:
                       1064-3745=1940-6029 ; ISBN:
                       978-1-0716-5018-9=978-1-0716-5019-6 ;
                       doi:10.1007/978-1-0716-5019-6},
      abstract     = {Pathogenic dimorphic fungi are endemic in certain regions
                      and can cause from subclinical infections to systemic
                      mycoses. These pathogens are associated with high mortality
                      and morbidity rates and represent emerging infectious
                      threats to human populations worldwide. Because most fungal
                      pathogens cause lung infection or use the lung as a route to
                      disseminate to other organs, mammalian pulmonary infection
                      models are crucial tools in the advancement of medical
                      mycology. Many different types of animal models of fungal
                      infection have been developed, with murine models being
                      hailed as the gold standard for studies of pathogenesis, to
                      compare virulence between isolates, preclinical evaluation
                      of vaccines and therapies, and host antifungal immune
                      responses. The ability to control numerous variables in
                      performing the model allows for mimicking human disease
                      states and quantitatively monitoring the course of the
                      disease. To model lung inflammation and injury, fungal
                      infectious propagules can be inoculated via intranasal
                      delivery, intratracheal, or aerosolization approaches. The
                      protocol in this chapter details a method for intratracheal
                      delivery of a fungal suspension, where fungal cells are
                      administered directly into the lungs to initiate infection.
                      The aim is to provide a comprehensive description of
                      techniques required to perform mouse pulmonary infection,
                      such that reproducible results are attained, allowing for
                      the use of this in vivo approach for high-quality studies.},
      keywords     = {Animals / Mice / Disease Models, Animal / Lung:
                      microbiology / Lung: pathology / Lung Diseases, Fungal:
                      microbiology / Lung Diseases, Fungal: pathology / Trachea:
                      microbiology / Fungal infection (Other) / Immune response
                      (Other) / Intratracheal instillation (Other) / Mouse model
                      (Other) / Pathogenesis (Other) / Pulmonary disease (Other)},
      cin          = {AG Di Monte},
      ddc          = {570},
      cid          = {I:(DE-2719)1013008},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)7},
      pubmed       = {pmid:41478930},
      doi          = {10.1007/978-1-0716-5019-6_3},
      url          = {https://pub.dzne.de/record/283120},
}