TY  - JOUR
AU  - Müller, Laura
AU  - Özdüzenciler, Pelin
AU  - Schedlich-Teufer, Charlotte
AU  - Seger, Aline
AU  - Jergas, Hannah
AU  - Fink, Gereon R
AU  - Willbold, Dieter
AU  - Sommerauer, Michael
AU  - Barbe, Michael T
AU  - Tamgüney, Gültekin
TI  - Elevated α-Synuclein Aggregate Levels in the Urine of Patients with Isolated REM Sleep Behavior Disorder and Parkinson's Disease.
JO  - Annals of neurology
VL  - 98
IS  - 1
SN  - 0364-5134
CY  - Hoboken, NJ
PB  - Wiley-Blackwell
M1  - DZNE-2026-00028
SP  - 147 - 151
PY  - 2025
AB  - Parkinson's disease (PD) is a neurodegenerative disorder characterized by α-synuclein aggregation in neurons. Recent advances suggest α-synuclein aggregates could serve as a biomarker for PD and related synucleinopathies. This study used surface-based fluorescence intensity distribution analysis (sFIDA) to measure α-synuclein aggregates in urine. Patients with PD and isolated rapid eye movement sleep behavior disorder, a precursor to PD, had elevated concentrations compared with healthy controls. Sensitivity and specificity were 83
KW  - Humans
KW  - Parkinson Disease: urine
KW  - Parkinson Disease: diagnosis
KW  - REM Sleep Behavior Disorder: urine
KW  - REM Sleep Behavior Disorder: diagnosis
KW  - alpha-Synuclein: urine
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - Aged
KW  - Biomarkers: urine
KW  - Sensitivity and Specificity
KW  - alpha-Synuclein (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40285625
C2  - pmc:PMC12174725
DO  - DOI:10.1002/ana.27250
UR  - https://pub.dzne.de/record/283132
ER  -