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| Home > Institute Collections > BN DZNE > BN DZNE-LIS > Elevated α-Synuclein Aggregate Levels in the Urine of Patients with Isolated REM Sleep Behavior Disorder and Parkinson's Disease. |
| Home > Institute Collections > BN DZNE > BN DZNE-LIS > Elevated α-Synuclein Aggregate Levels in the Urine of Patients with Isolated REM Sleep Behavior Disorder and Parkinson's Disease. |
| Journal Article | DZNE-2026-00028 |
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2025
Wiley-Blackwell
Hoboken, NJ
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Please use a persistent id in citations: doi:10.1002/ana.27250
Abstract: Parkinson's disease (PD) is a neurodegenerative disorder characterized by α-synuclein aggregation in neurons. Recent advances suggest α-synuclein aggregates could serve as a biomarker for PD and related synucleinopathies. This study used surface-based fluorescence intensity distribution analysis (sFIDA) to measure α-synuclein aggregates in urine. Patients with PD and isolated rapid eye movement sleep behavior disorder, a precursor to PD, had elevated concentrations compared with healthy controls. Sensitivity and specificity were 83% and 65% for PD versus controls and 89% and 62% for isolated rapid eye movement sleep behavior disorder versus controls. The findings highlight sFIDA's potential for diagnosing synucleinopathies. ANN NEUROL 2025;98:147-151.
Keyword(s): Humans (MeSH) ; Parkinson Disease: urine (MeSH) ; Parkinson Disease: diagnosis (MeSH) ; REM Sleep Behavior Disorder: urine (MeSH) ; REM Sleep Behavior Disorder: diagnosis (MeSH) ; alpha-Synuclein: urine (MeSH) ; Male (MeSH) ; Female (MeSH) ; Middle Aged (MeSH) ; Aged (MeSH) ; Biomarkers: urine (MeSH) ; Sensitivity and Specificity (MeSH) ; alpha-Synuclein ; Biomarkers
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