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@ARTICLE{Klassen:283139,
      author       = {Klassen, Paula Cynthia and Alexudis, Christoforos and
                      Klose, Veronika and de San José, Nerea Gómez and Huss,
                      André and Bachhuber, Franziska and Soylu, Önder and
                      Fazeli, Badrieh and Erhart, Deborah and Laible, Mona and
                      Anderl-Straub, Sarah and Jesse, Sarah and Otto, Markus and
                      Ludolph, Albert and Tumani, Hayrettin and Halbgebauer,
                      Steffen},
      title        = {{I}ncreased transmembrane protein 119 ({TMEM}119) levels in
                      the cerebrospinal fluid of patients with mild cognitive
                      impairment due to {A}lzheimer's disease suggest early
                      microglial involvement.},
      journal      = {Alzheimer's $\&$ dementia / Diagnosis, assessment $\&$
                      disease monitoring},
      volume       = {18},
      number       = {1},
      issn         = {2352-8729},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2026-00035},
      pages        = {e70240},
      year         = {2026},
      abstract     = {We aimed to evaluate the potential of the microglial marker
                      transmembrane protein 119 (TMEM119) in the cerebrospinal
                      fluid (CSF) as a (differential) diagnostic biomarker for
                      neurodegenerative diseases.Following assay validation, we
                      used enzyme-linked immunosorbent assay to measure CSF
                      TMEM119 in 174 patients from six diagnostic groups:
                      Alzheimer's disease (AD, n = 35), amyotrophic lateral
                      sclerosis (ALS, n = 33), cerebral microangiopathy (CM, n =
                      25), frontotemporal lobar degeneration (FTLD, n = 28), Lewy
                      body diseases (n = 21), and non-neurodegenerative controls
                      (n = 33).CSF TMEM119 levels were elevated in the AD group
                      compared to the control (p = 0.004), CM (p = 0.005), and
                      FTLD (p = 0.023) groups. Levels were higher in both mild
                      cognitive impairment (MCI-AD) and dementia (ADD) subgroups
                      when compared to controls. For the discrimination of AD from
                      controls, the area under the curve (AUC) was 0.78.Our
                      results indicate that CSF TMEM119 may have potential as a
                      biomarker representing microglial involvement in early and
                      later stages of AD.Elevated levels of TMEM119 were observed
                      in the CSF of patients with AD.Increased CSF TMEM119 was
                      seen in MCI-AD patients compared to controls.Elevated levels
                      in MCI-AD underscore early microglial involvement in AD.In
                      the AD group, an association was found between CSF TMEM119
                      and CSF total tau.CSF TMEM119 may provide valuable
                      information on neuroinflammation.},
      keywords     = {Alzheimer's disease (Other) / biomarkers (Other) /
                      cerebrospinal fluid (Other) / microglia (Other) /
                      neuroinflammation (Other)},
      cin          = {Clinical Study Center (Ulm) / AG Zhan},
      ddc          = {610},
      cid          = {I:(DE-2719)5000077 / I:(DE-2719)1910005},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 354 -
                      Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41488805},
      pmc          = {pmc:PMC12756045},
      doi          = {10.1002/dad2.70240},
      url          = {https://pub.dzne.de/record/283139},
}