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000283142 1001_ $$aHegelmaier, Tobias$$b0
000283142 245__ $$aSupplementation with short-chain fatty acids and a prebiotic improves clinical outcome in Parkinson's disease: a randomized double-blind prospective study.
000283142 260__ $$a[London]$$bSpringer Nature$$c2025
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000283142 520__ $$aParkinson's disease is associated with a dysbiotic, proinflammatory gut microbiome, disruptions to intestinal barrier functions, and immunological imbalance. Microbiota-produced short-chain fatty acids, such as propionic and butyric acid promote gut barrier integrity and immune regulation, but their impact on Parkinson's disease pathology remains mostly unknown.In a randomized double-blind prospective study, 72 people with Parkinson's disease received propionic and butyric acid and/or the prebiotic fiber 2'-fucosyllactose supplementation over 6 months in combination with existing Parkinson's disease-specific therapy. Patients underwent complete neurological assessment and provided blood and stool samples before as well as 3 and 6 months after supplementation.We observed a robust improvement in motor symptoms, with all intervention groups achieving clinically meaningful reductions. These motor benefits were paralleled by clinically relevant reductions in levodopa medication. In contrast, effects on nonmotor symptoms were more heterogeneous. Notably, the interventions also modulated peripheral immune responses and enhanced mitochondrial respiration in immunocytes. Postintervention microbiota remodeled inflammatory and barrier-related gene sets in gut organ cultures and improved in vitro barrier functions. Treatment response was associated with microbiome composition, distinct patterns of colonic transcription and permeability ex vivo. Multiobjective analysis revealed immune parameters associated with an optimal response to supplementation.Short-chain fatty acids ameliorate clinical symptoms in Parkinson's disease patients and modulate intestinal and peripheral immunity.This clinical trial was retrospectively registered with the German Clinical Trials Register (DRKS), registration number DRKS00027061 on 11/19/2021.
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000283142 650_7 $$2Other$$aClinical improvement
000283142 650_7 $$2Other$$aGut microbiome
000283142 650_7 $$2Other$$aImmunomodulation
000283142 650_7 $$2Other$$aNeurodegeneration
000283142 650_7 $$2Other$$aNeuroinflammation
000283142 650_7 $$2Other$$aParkinson’s disease
000283142 650_7 $$2Other$$aShort chain fatty acids
000283142 650_7 $$2NLM Chemicals$$aPrebiotics
000283142 650_7 $$2NLM Chemicals$$aFatty Acids, Volatile
000283142 650_2 $$2MeSH$$aHumans
000283142 650_2 $$2MeSH$$aParkinson Disease: microbiology
000283142 650_2 $$2MeSH$$aParkinson Disease: diet therapy
000283142 650_2 $$2MeSH$$aParkinson Disease: drug therapy
000283142 650_2 $$2MeSH$$aPrebiotics: administration & dosage
000283142 650_2 $$2MeSH$$aMale
000283142 650_2 $$2MeSH$$aDouble-Blind Method
000283142 650_2 $$2MeSH$$aFemale
000283142 650_2 $$2MeSH$$aFatty Acids, Volatile: administration & dosage
000283142 650_2 $$2MeSH$$aGastrointestinal Microbiome: drug effects
000283142 650_2 $$2MeSH$$aAged
000283142 650_2 $$2MeSH$$aMiddle Aged
000283142 650_2 $$2MeSH$$aDietary Supplements
000283142 650_2 $$2MeSH$$aProspective Studies
000283142 650_2 $$2MeSH$$aTreatment Outcome
000283142 7001_ $$aDuscha, Alexander$$b1
000283142 7001_ $$aDesel, Christiane$$b2
000283142 7001_ $$aFuchs, Sabrina$$b3
000283142 7001_ $$aShapira, Michal$$b4
000283142 7001_ $$aAmidror, Sivan$$b5
000283142 7001_ $$aShan, Qihao$$b6
000283142 7001_ $$aStangl, Gabriele I$$b7
000283142 7001_ $$aHirche, Frank$$b8
000283142 7001_ $$aKempa, Stefan$$b9
000283142 7001_ $$aMaifeld, András$$b10
000283142 7001_ $$aWürtele, Lisa-Marie$$b11
000283142 7001_ $$aPeplinski, Jana$$b12
000283142 7001_ $$aJauk, Diana$$b13
000283142 7001_ $$aNaim, Gitali$$b14
000283142 7001_ $$aShidlovsky, Nuphar$$b15
000283142 7001_ $$aCohen, Adva$$b16
000283142 7001_ $$aBennet, Yifat$$b17
000283142 7001_ $$aPaschold, Lisa$$b18
000283142 7001_ $$aDumitru, Claudia A$$b19
000283142 7001_ $$aObermüller-Jevic, Ute$$b20
000283142 7001_ $$aHustvedt, Svein-Olaf$$b21
000283142 7001_ $$aTimmesfeld, Nina$$b22
000283142 7001_ $$aGold, Ralf$$b23
000283142 7001_ $$aZapf, Antonia$$b24
000283142 7001_ $$aBinder, Mascha$$b25
000283142 7001_ $$aSandalcioglu, Ibrahim E$$b26
000283142 7001_ $$aMostaghim, Sanaz$$b27
000283142 7001_ $$aPrzuntek, Horst$$b28
000283142 7001_ $$aSegal, Eran$$b29
000283142 7001_ $$aYissachar, Nissan$$b30
000283142 7001_ $$0P:(DE-2719)9001370$$aHaghikia, Aiden$$b31$$eLast author$$udzne
000283142 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-025-29692-x$$gVol. 16, no. 1, p. 315$$n1$$p315$$tScientific reports$$v16$$x2045-2322$$y2025
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