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000283143 1001_ $$aNajar, Jenna$$b0
000283143 245__ $$aPolygenic risk for psychiatric disorders and its association with neuropsychiatric symptoms in dementia.
000283143 260__ $$aAbingdon$$bTaylor & Francis Group$$c2025
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000283143 520__ $$aNeuropsychiatric symptoms are common in Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD), yet their genetic underpinnings remain unclear. To gain insight into biological processes related to neuropsychiatric symptoms in dementia, we investigated whether polygenic risk scores (PRS) for psychiatric disorders - major depressive disorder (MDD), schizophrenia (SCZ), bipolar disorder (BD), and autism spectrum disorder (ASD) - are associated with neuropsychiatric symptoms in dementia. Data included genetic and neuropsychiatric data of 6240 AD patients, 428 FTD patients and 390 DLB patients from five European cohorts (ADC, GR@ACE, DELCODE, AgeCoDe, and DCN). PRS for MDD, BD, SCZ, and ASD were calculated using LDpred2. Neuropsychiatric symptoms were assessed using total scores from the Neuropsychiatric Inventory (NPI) (NPI-12 and NPI-Q) and Geriatric Depression scale (GDS). Associations between PRS and symptoms were examined using linear regression models, followed by meta-analyses. In FTD, higher SCZ-PRS associated with lower NPI scores in the meta-analysis (β = -0.12, p = .001). No associations were found in AD and DLB. This is the first study to show that genetic liability for SCZ associates with lower NPI in FTD, warranting further investigation.
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000283143 650_7 $$2Other$$aDementia
000283143 650_7 $$2Other$$afrontotemporal dementia
000283143 650_7 $$2Other$$aneuropsychiatric symptoms
000283143 650_7 $$2Other$$apolygenic risk scores
000283143 650_7 $$2Other$$apsychiatric disorders
000283143 650_2 $$2MeSH$$aHumans
000283143 650_2 $$2MeSH$$aMultifactorial Inheritance: genetics
000283143 650_2 $$2MeSH$$aAged
000283143 650_2 $$2MeSH$$aMale
000283143 650_2 $$2MeSH$$aFemale
000283143 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000283143 650_2 $$2MeSH$$aLewy Body Disease: genetics
000283143 650_2 $$2MeSH$$aFrontotemporal Dementia: genetics
000283143 650_2 $$2MeSH$$aDepressive Disorder, Major: genetics
000283143 650_2 $$2MeSH$$aBipolar Disorder: genetics
000283143 650_2 $$2MeSH$$aGenetic Predisposition to Disease
000283143 650_2 $$2MeSH$$aSchizophrenia: genetics
000283143 650_2 $$2MeSH$$aSchizophrenia: physiopathology
000283143 650_2 $$2MeSH$$aAutism Spectrum Disorder: genetics
000283143 650_2 $$2MeSH$$aDementia: genetics
000283143 650_2 $$2MeSH$$aMiddle Aged
000283143 650_2 $$2MeSH$$aMental Disorders: genetics
000283143 650_2 $$2MeSH$$aAged, 80 and over
000283143 7001_ $$ade Rojas, Itziar$$b1
000283143 7001_ $$0P:(DE-HGF)0$$aDalmasso, Maria Carolina$$b2
000283143 7001_ $$aFernandez, Maria Victoria$$b3
000283143 7001_ $$ade Boer, Sterre C M$$b4
000283143 7001_ $$0P:(DE-2719)2812825$$aRamirez, Alfredo$$b5$$udzne
000283143 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b6$$udzne
000283143 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b7$$udzne
000283143 7001_ $$0P:(DE-2719)2812139$$aKleineidam, Luca$$b8$$udzne
000283143 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b9$$udzne
000283143 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b10$$udzne
000283143 7001_ $$0P:(DE-HGF)0$$aHeilmann-Heimbach, Stefanie$$b11
000283143 7001_ $$0P:(DE-HGF)0$$aScherer, Martin$$b12
000283143 7001_ $$0P:(DE-HGF)0$$aFroelich, Lutz$$b13
000283143 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b14$$udzne
000283143 7001_ $$0P:(DE-2719)9003016$$aHellmann-Regen, Julian David Nicolai$$b15$$udzne
000283143 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b16$$udzne
000283143 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b17$$udzne
000283143 7001_ $$0P:(DE-2719)2811351$$aBuerger, Katharina$$b18$$udzne
000283143 7001_ $$0P:(DE-2719)2812234$$aPerneczky, Robert$$b19$$udzne
000283143 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b20$$udzne
000283143 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b21$$udzne
000283143 7001_ $$aKornhuber, Johannes$$b22
000283143 7001_ $$aLemstra, Afina W$$b23
000283143 7001_ $$aPijnenburg, Yolande A L$$b24
000283143 7001_ $$avan der Lee, Sven J$$b25
000283143 7001_ $$aReus, Lianne M$$b26
000283143 773__ $$0PERI:(DE-600)2009829-7$$a10.1080/09540261.2025.2600619$$gVol. 37, no. 8, p. 816 - 826$$n8$$p816 - 826$$tInternational review of psychiatry$$v37$$x0954-0261$$y2025
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