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@ARTICLE{Najar:283143,
      author       = {Najar, Jenna and de Rojas, Itziar and Dalmasso, Maria
                      Carolina and Fernandez, Maria Victoria and de Boer, Sterre C
                      M and Ramirez, Alfredo and Priller, Josef and Laske,
                      Christoph and Kleineidam, Luca and Schneider, Anja and
                      Wagner, Michael and Heilmann-Heimbach, Stefanie and Scherer,
                      Martin and Froelich, Lutz and Peters, Oliver and
                      Hellmann-Regen, Julian David Nicolai and Wiltfang, Jens and
                      Düzel, Emrah and Buerger, Katharina and Perneczky, Robert
                      and Teipel, Stefan and Jessen, Frank and Kornhuber, Johannes
                      and Lemstra, Afina W and Pijnenburg, Yolande A L and van der
                      Lee, Sven J and Reus, Lianne M},
      title        = {{P}olygenic risk for psychiatric disorders and its
                      association with neuropsychiatric symptoms in dementia.},
      journal      = {International review of psychiatry},
      volume       = {37},
      number       = {8},
      issn         = {0954-0261},
      address      = {Abingdon},
      publisher    = {Taylor $\&$ Francis Group},
      reportid     = {DZNE-2026-00039},
      pages        = {816 - 826},
      year         = {2025},
      abstract     = {Neuropsychiatric symptoms are common in Alzheimer's disease
                      (AD), dementia with Lewy bodies (DLB), and frontotemporal
                      dementia (FTD), yet their genetic underpinnings remain
                      unclear. To gain insight into biological processes related
                      to neuropsychiatric symptoms in dementia, we investigated
                      whether polygenic risk scores (PRS) for psychiatric
                      disorders - major depressive disorder (MDD), schizophrenia
                      (SCZ), bipolar disorder (BD), and autism spectrum disorder
                      (ASD) - are associated with neuropsychiatric symptoms in
                      dementia. Data included genetic and neuropsychiatric data of
                      6240 AD patients, 428 FTD patients and 390 DLB patients from
                      five European cohorts (ADC, GR@ACE, DELCODE, AgeCoDe, and
                      DCN). PRS for MDD, BD, SCZ, and ASD were calculated using
                      LDpred2. Neuropsychiatric symptoms were assessed using total
                      scores from the Neuropsychiatric Inventory (NPI) (NPI-12 and
                      NPI-Q) and Geriatric Depression scale (GDS). Associations
                      between PRS and symptoms were examined using linear
                      regression models, followed by meta-analyses. In FTD, higher
                      SCZ-PRS associated with lower NPI scores in the
                      meta-analysis (β = -0.12, p = .001). No associations were
                      found in AD and DLB. This is the first study to show that
                      genetic liability for SCZ associates with lower NPI in FTD,
                      warranting further investigation.},
      keywords     = {Humans / Multifactorial Inheritance: genetics / Aged / Male
                      / Female / Alzheimer Disease: genetics / Lewy Body Disease:
                      genetics / Frontotemporal Dementia: genetics / Depressive
                      Disorder, Major: genetics / Bipolar Disorder: genetics /
                      Genetic Predisposition to Disease / Schizophrenia: genetics
                      / Schizophrenia: physiopathology / Autism Spectrum Disorder:
                      genetics / Dementia: genetics / Middle Aged / Mental
                      Disorders: genetics / Aged, 80 and over / Dementia (Other) /
                      frontotemporal dementia (Other) / neuropsychiatric symptoms
                      (Other) / polygenic risk scores (Other) / psychiatric
                      disorders (Other)},
      cin          = {Patient Studies (Bonn) / AG Priller / AG Gasser / AG Wagner
                      / AG Schneider / AG Wiltfang / AG Jessen / AG Peters / AG
                      Düzel / Clinical Research (Munich) / AG Dichgans / AG
                      Teipel},
      ddc          = {610},
      cid          = {I:(DE-2719)1011101 / I:(DE-2719)5000007 /
                      I:(DE-2719)1210000 / I:(DE-2719)1011201 / I:(DE-2719)1011305
                      / I:(DE-2719)1410006 / I:(DE-2719)1011102 /
                      I:(DE-2719)5000000 / I:(DE-2719)5000006 / I:(DE-2719)1111015
                      / I:(DE-2719)5000022 / I:(DE-2719)1510100},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41437785},
      doi          = {10.1080/09540261.2025.2600619},
      url          = {https://pub.dzne.de/record/283143},
}