%0 Conference Paper
%A Rodríguez-Baz, Íñigo
%A Bernhardt, Alexander M
%A Aldecoa, Iban
%A Arranz, Javier
%A Arriola-Infante, José Enrique
%A Maure-Blesa, Lucía
%A Carmona-Iragui, Maria
%A Longen, Sebastian
%A Trossbach, Svenja Verena
%A Giese, Armin
%A Matthias, Torsten
%A Benejam, Bessy
%A Videla, Laura
%A Hoyo, Laura Del
%A Barroeta, Isabel
%A Hernandez, Aida Sanjuan
%A Fernandez, Susana
%A Vaqué-Alcázar, Lídia
%A Aranha, Mateus Rozalem
%A Morcillo-Nieto, Alejandra O
%A Nübling, Georg
%A Wagemann, Olivia
%A Stockbauer, Anna
%A Tondo, Mireia
%A Bejanin, Alexandre
%A Lleó, Alberto
%A Alcolea, Daniel
%A Molina, Laura
%A Fortea, Juan
%A Levin, Johannes
%T Alpha-Synuclein Pathology in Down Syndrome-Associated Alzheimer's Disease: Insights from Seed Amplification Assay and Neuropathology
%J Alzheimer's and dementia
%V 21
%N S2
%@ 1552-5260
%M DZNE-2026-00046
%P e106390
%D 2025
%X Down syndrome (DS) is a genetic cause of Alzheimer's disease (AD), with virtually all individuals developing AD pathology by their fourth decade due to Amyloid Precursor Protein (APP) gene overexpression. In addition to amyloid beta (Aβ) plaques and hyperphosphorylated tau (p-Tau) aggregates, DS-associated AD (DSAD) often includes α-synuclein (αSyn) aggregates, contributing to Lewy body pathology (LBP). The αSyn Seed Amplification Assay (SAA) in cerebrospinal fluid (CSF) enables the in vivo detection of misfolded αSyn. While αSyn-SAA has revealed αSyn pathology in autosomal dominant (6
%B Alzheimer’s Association International Conference
%C 27 Jul 2025 - 31 Jul 2025, Toronto (Canada)
Y2 27 Jul 2025 - 31 Jul 2025
M2 Toronto, Canada
%K Humans
%K Biomarkers: cerebrospinal fluid
%K Male
%K Female
%K Alzheimer Disease: cerebrospinal fluid
%K Alzheimer Disease: pathology
%K alpha-Synuclein: cerebrospinal fluid
%K Amyloid beta-Peptides: cerebrospinal fluid
%K Down Syndrome: cerebrospinal fluid
%K Down Syndrome: pathology
%K Middle Aged
%K tau Proteins: cerebrospinal fluid
%K Aged
%K Adult
%K Neurofilament Proteins: cerebrospinal fluid
%K Cohort Studies
%K Peptide Fragments: cerebrospinal fluid
%K Biomarkers (NLM Chemicals)
%K alpha-Synuclein (NLM Chemicals)
%K Amyloid beta-Peptides (NLM Chemicals)
%K tau Proteins (NLM Chemicals)
%K Neurofilament Proteins (NLM Chemicals)
%K Peptide Fragments (NLM Chemicals)
%F PUB:(DE-HGF)1 ; PUB:(DE-HGF)16
%9 AbstractJournal Article
%$ pmid:41500202
%R 10.1002/alz70856_106390
%U https://pub.dzne.de/record/283150