TY  - JOUR
AU  - Stascheit, Frauke
AU  - Preßler, Hannah
AU  - Stein, Kerstin
AU  - Pernice, Helena Franziska
AU  - Hahn, Katrin
AU  - Meisel, Andreas
AU  - Lünemann, Jan D
TI  - Aberrant Complement Activation Is a Prominent Feature of Chronic Inflammatory Demyelinating Polyneuropathy.
JO  - Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology
VL  - 13
IS  - 2
SN  - 2332-7812
CY  - Philadelphia, Pa.
PB  - Wolters Kluwer
M1  - DZNE-2026-00048
SP  - e200542
PY  - 2026
AB  - To comprehensively characterize complement pathway activation in chronic inflammatory demyelinating polyneuropathy (CIDP) and its association with clinical disease features using advanced complement profiling.Complement protein levels indicative of classical, lectin, and alternative pathway activation were quantified by multiplex ELISA and compared between 28 patients with typical CIDP, 24 patients with Charcot-Marie Tooth neuropathy (CMT), and 24 demographically matched healthy controls (HD).Serum levels of activated complement proteins-C3a, C4a, Ba, Bb, C5a, and the soluble terminal complement complex sC5b-9 (sTCC)-were significantly elevated in CIDP patients compared to healthy donors (HD) (p < 0.001). Except for C3a, these protein levels were also significantly higher in CIDP patients than in those with Charcot-Marie-Tooth disease (CMT). Among CIDP patients, those with active, unstable disease exhibited significantly higher levels of terminal complement components (C5a and sTCC) compared to patients with stable disease or in remission (p < 0.001).These findings highlight the critical involvement of aberrant complement activation in the pathophysiology of CIDP and provide a rationale for further investigation into targeted complement inhibition as a therapeutic approach.
KW  - Humans
KW  - Polyradiculoneuropathy, Chronic Inflammatory Demyelinating: blood
KW  - Polyradiculoneuropathy, Chronic Inflammatory Demyelinating: immunology
KW  - Polyradiculoneuropathy, Chronic Inflammatory Demyelinating: physiopathology
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - Complement Activation: physiology
KW  - Adult
KW  - Charcot-Marie-Tooth Disease: blood
KW  - Charcot-Marie-Tooth Disease: immunology
KW  - Aged
LB  - PUB:(DE-HGF)16
C6  - pmid:41499725
DO  - DOI:10.1212/NXI.0000000000200542
UR  - https://pub.dzne.de/record/283152
ER  -