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000283179 1001_ $$aDiekmann, Christina$$b0
000283179 245__ $$aFat Amount Rather Than Fatty Acid Composition Influences Postprandial Hunger, Satiety and Attention in Men and Women with a Risk Phenotype for Cardiometabolic Diseases: A Randomized Crossover Trial.
000283179 260__ $$aAmsterdam$$bElsevier$$c2026
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000283179 520__ $$aHunger and satiety are influenced by both the amount and composition of dietary fat.This exploratory analysis examined the effects of meals enriched with different amounts of either canola oil (rich in unsaturated fatty acids) or coconut oil (rich in saturated fatty acids) on postprandial changes in subjective hunger and satiety ratings, related hormones, attention, and memory.Twenty-nine participants with an increased cardiometabolic disease risk (e.g., body mass index, 30.2 ± 2.6 kg/m2) received 4 isoenergetic (∼4200 kJ) test meals in a randomized order: high-fat meals (HFMs) (50 g) or low-fat meals (LFMs) (25 g) containing either canola or coconut oil. Hunger and satiety ratings, blood samples for ghrelin and peptide YY (PYY), and cognitive tests were conducted at fasting and over a 6-h postprandial period. The data were analyzed via linear mixed models.Lower serum ghrelin levels were observed after canola oil meals [canola compared with coconut: -27,700 (confidence interval: -40,700, -14,700) min × pg/mL] with no effect of fat amount on incremental area under the curve data [HFM compared with LFM: -9500 (-22,500, 3500) min × pg/mL]. Serum PYY concentrations were higher after HFMs [HFM compared with LFM: 8600 (2100, 15,200) min × pg/mL]. LFMs resulted in lower subjective hunger ratings compared with HFMs [HFM compared with LFM: 250 (71, 430) min × score-value].Our data indicate that predominantly the amount of dietary fat, rather than its type, affects hunger and satiety. At the hormonal level, canola oil suppressed postprandial hunger to a greater extent than coconut oil. This trial was registered at ClinicalTrials.gov (https://clinicaltrials.gov/) as NCT05208346.
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000283179 650_7 $$2Other$$aattention
000283179 650_7 $$2Other$$acanola oil
000283179 650_7 $$2Other$$acoconut oil
000283179 650_7 $$2Other$$apostprandial metabolism
000283179 650_7 $$2Other$$asatiety
000283179 650_7 $$2NLM Chemicals$$aDietary Fats
000283179 650_7 $$2NLM Chemicals$$aFatty Acids
000283179 650_7 $$2NLM Chemicals$$aGhrelin
000283179 650_7 $$2NLM Chemicals$$aRapeseed Oil
000283179 650_7 $$0Q9L0O73W7L$$2NLM Chemicals$$aCoconut Oil
000283179 650_2 $$2MeSH$$aHumans
000283179 650_2 $$2MeSH$$aFemale
000283179 650_2 $$2MeSH$$aMale
000283179 650_2 $$2MeSH$$aHunger: drug effects
000283179 650_2 $$2MeSH$$aCross-Over Studies
000283179 650_2 $$2MeSH$$aPostprandial Period
000283179 650_2 $$2MeSH$$aSatiation: drug effects
000283179 650_2 $$2MeSH$$aDietary Fats: administration & dosage
000283179 650_2 $$2MeSH$$aDietary Fats: pharmacology
000283179 650_2 $$2MeSH$$aAdult
000283179 650_2 $$2MeSH$$aFatty Acids: administration & dosage
000283179 650_2 $$2MeSH$$aFatty Acids: pharmacology
000283179 650_2 $$2MeSH$$aMiddle Aged
000283179 650_2 $$2MeSH$$aGhrelin: blood
000283179 650_2 $$2MeSH$$aAttention: drug effects
000283179 650_2 $$2MeSH$$aRapeseed Oil: administration & dosage
000283179 650_2 $$2MeSH$$aCoconut Oil: administration & dosage
000283179 650_2 $$2MeSH$$aCardiovascular Diseases
000283179 7001_ $$aSchiemann, Tim B$$b1
000283179 7001_ $$aKienēs, Hannah F$$b2
000283179 7001_ $$aWiechmann, Carolin$$b3
000283179 7001_ $$aKopp, Christina$$b4
000283179 7001_ $$aStoffel-Wagner, Birgit$$b5
000283179 7001_ $$aCoenen, Martin$$b6
000283179 7001_ $$aNémeth, Robert$$b7
000283179 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b8$$udzne
000283179 7001_ $$aEgert, Sarah$$b9
000283179 773__ $$0PERI:(DE-600)1469429-3$$a10.1016/j.tjnut.2025.11.003$$gVol. 156, no. 1, p. 101232 -$$n1$$p101232$$tThe journal of nutrition$$v156$$x0022-3166$$y2026
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