TY  - JOUR
AU  - Diekmann, Christina
AU  - Schiemann, Tim B
AU  - Kienēs, Hannah F
AU  - Wiechmann, Carolin
AU  - Kopp, Christina
AU  - Stoffel-Wagner, Birgit
AU  - Coenen, Martin
AU  - Németh, Robert
AU  - Wagner, Michael
AU  - Egert, Sarah
TI  - Fat Amount Rather Than Fatty Acid Composition Influences Postprandial Hunger, Satiety and Attention in Men and Women with a Risk Phenotype for Cardiometabolic Diseases: A Randomized Crossover Trial.
JO  - The journal of nutrition
VL  - 156
IS  - 1
SN  - 0022-3166
CY  - Amsterdam
PB  - Elsevier
M1  - DZNE-2026-00058
SP  - 101232
PY  - 2026
AB  - Hunger and satiety are influenced by both the amount and composition of dietary fat.This exploratory analysis examined the effects of meals enriched with different amounts of either canola oil (rich in unsaturated fatty acids) or coconut oil (rich in saturated fatty acids) on postprandial changes in subjective hunger and satiety ratings, related hormones, attention, and memory.Twenty-nine participants with an increased cardiometabolic disease risk (e.g., body mass index, 30.2 ± 2.6 kg/m2) received 4 isoenergetic (∼4200 kJ) test meals in a randomized order: high-fat meals (HFMs) (50 g) or low-fat meals (LFMs) (25 g) containing either canola or coconut oil. Hunger and satiety ratings, blood samples for ghrelin and peptide YY (PYY), and cognitive tests were conducted at fasting and over a 6-h postprandial period. The data were analyzed via linear mixed models.Lower serum ghrelin levels were observed after canola oil meals [canola compared with coconut: -27,700 (confidence interval: -40,700, -14,700) min × pg/mL] with no effect of fat amount on incremental area under the curve data [HFM compared with LFM: -9500 (-22,500, 3500) min × pg/mL]. Serum PYY concentrations were higher after HFMs [HFM compared with LFM: 8600 (2100, 15,200) min × pg/mL]. LFMs resulted in lower subjective hunger ratings compared with HFMs [HFM compared with LFM: 250 (71, 430) min × score-value].Our data indicate that predominantly the amount of dietary fat, rather than its type, affects hunger and satiety. At the hormonal level, canola oil suppressed postprandial hunger to a greater extent than coconut oil. This trial was registered at ClinicalTrials.gov (https://clinicaltrials.gov/) as NCT05208346.
KW  - Humans
KW  - Female
KW  - Male
KW  - Hunger: drug effects
KW  - Cross-Over Studies
KW  - Postprandial Period
KW  - Satiation: drug effects
KW  - Dietary Fats: administration & dosage
KW  - Dietary Fats: pharmacology
KW  - Adult
KW  - Fatty Acids: administration & dosage
KW  - Fatty Acids: pharmacology
KW  - Middle Aged
KW  - Ghrelin: blood
KW  - Attention: drug effects
KW  - Rapeseed Oil: administration & dosage
KW  - Coconut Oil: administration & dosage
KW  - Cardiovascular Diseases
KW  - attention (Other)
KW  - canola oil (Other)
KW  - coconut oil (Other)
KW  - postprandial metabolism (Other)
KW  - satiety (Other)
KW  - Dietary Fats (NLM Chemicals)
KW  - Fatty Acids (NLM Chemicals)
KW  - Ghrelin (NLM Chemicals)
KW  - Rapeseed Oil (NLM Chemicals)
KW  - Coconut Oil (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41232773
DO  - DOI:10.1016/j.tjnut.2025.11.003
UR  - https://pub.dzne.de/record/283179
ER  -