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@ARTICLE{Diekmann:283179,
      author       = {Diekmann, Christina and Schiemann, Tim B and Kienēs,
                      Hannah F and Wiechmann, Carolin and Kopp, Christina and
                      Stoffel-Wagner, Birgit and Coenen, Martin and Németh,
                      Robert and Wagner, Michael and Egert, Sarah},
      title        = {{F}at {A}mount {R}ather {T}han {F}atty {A}cid {C}omposition
                      {I}nfluences {P}ostprandial {H}unger, {S}atiety and
                      {A}ttention in {M}en and {W}omen with a {R}isk {P}henotype
                      for {C}ardiometabolic {D}iseases: {A} {R}andomized
                      {C}rossover {T}rial.},
      journal      = {The journal of nutrition},
      volume       = {156},
      number       = {1},
      issn         = {0022-3166},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DZNE-2026-00058},
      pages        = {101232},
      year         = {2026},
      abstract     = {Hunger and satiety are influenced by both the amount and
                      composition of dietary fat.This exploratory analysis
                      examined the effects of meals enriched with different
                      amounts of either canola oil (rich in unsaturated fatty
                      acids) or coconut oil (rich in saturated fatty acids) on
                      postprandial changes in subjective hunger and satiety
                      ratings, related hormones, attention, and memory.Twenty-nine
                      participants with an increased cardiometabolic disease risk
                      (e.g., body mass index, 30.2 ± 2.6 kg/m2) received 4
                      isoenergetic (∼4200 kJ) test meals in a randomized order:
                      high-fat meals (HFMs) (50 g) or low-fat meals (LFMs) (25 g)
                      containing either canola or coconut oil. Hunger and satiety
                      ratings, blood samples for ghrelin and peptide YY (PYY), and
                      cognitive tests were conducted at fasting and over a 6-h
                      postprandial period. The data were analyzed via linear mixed
                      models.Lower serum ghrelin levels were observed after canola
                      oil meals [canola compared with coconut: -27,700 (confidence
                      interval: -40,700, -14,700) min × pg/mL] with no effect of
                      fat amount on incremental area under the curve data [HFM
                      compared with LFM: -9500 (-22,500, 3500) min × pg/mL].
                      Serum PYY concentrations were higher after HFMs [HFM
                      compared with LFM: 8600 (2100, 15,200) min × pg/mL]. LFMs
                      resulted in lower subjective hunger ratings compared with
                      HFMs [HFM compared with LFM: 250 (71, 430) min ×
                      score-value].Our data indicate that predominantly the amount
                      of dietary fat, rather than its type, affects hunger and
                      satiety. At the hormonal level, canola oil suppressed
                      postprandial hunger to a greater extent than coconut oil.
                      This trial was registered at ClinicalTrials.gov
                      (https://clinicaltrials.gov/) as NCT05208346.},
      keywords     = {Humans / Female / Male / Hunger: drug effects / Cross-Over
                      Studies / Postprandial Period / Satiation: drug effects /
                      Dietary Fats: administration $\&$ dosage / Dietary Fats:
                      pharmacology / Adult / Fatty Acids: administration $\&$
                      dosage / Fatty Acids: pharmacology / Middle Aged / Ghrelin:
                      blood / Attention: drug effects / Rapeseed Oil:
                      administration $\&$ dosage / Coconut Oil: administration
                      $\&$ dosage / Cardiovascular Diseases / attention (Other) /
                      canola oil (Other) / coconut oil (Other) / postprandial
                      metabolism (Other) / satiety (Other) / Dietary Fats (NLM
                      Chemicals) / Fatty Acids (NLM Chemicals) / Ghrelin (NLM
                      Chemicals) / Rapeseed Oil (NLM Chemicals) / Coconut Oil (NLM
                      Chemicals)},
      cin          = {AG Wagner},
      ddc          = {610},
      cid          = {I:(DE-2719)1011201},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41232773},
      doi          = {10.1016/j.tjnut.2025.11.003},
      url          = {https://pub.dzne.de/record/283179},
}