Fat Amount Rather Than Fatty Acid Composition Influences Postprandial Hunger, Satiety and Attention in Men and Women with a Risk Phenotype for Cardiometabolic Diseases: A Randomized Crossover Trial.

Diekmann, Christina; Stoffel-Wagner, Birgit; Wiechmann, Carolin; Németh, Robert; Coenen, Martin; Schiemann, Tim B; Wagner, Michael; Egert, Sarah; Kienēs, Hannah F; Kopp, Christina

doi:10.1016/j.tjnut.2025.11.003

Items
Marc 21

001			283179
005			20260129104044.0
024	7	_	\|a 10.1016/j.tjnut.2025.11.003 \|2 doi
024	7	_	\|a pmid:41232773 \|2 pmid
024	7	_	\|a 0022-3166 \|2 ISSN
024	7	_	\|a 1541-6100 \|2 ISSN
037	_	_	\|a DZNE-2026-00058
041	_	_	\|a English
082	_	_	\|a 610
100	1	_	\|a Diekmann, Christina \|b 0
245	_	_	\|a Fat Amount Rather Than Fatty Acid Composition Influences Postprandial Hunger, Satiety and Attention in Men and Women with a Risk Phenotype for Cardiometabolic Diseases: A Randomized Crossover Trial.
260	_	_	\|a Amsterdam \|c 2026 \|b Elsevier
336	7	_	\|a article \|2 DRIVER
336	7	_	\|a Output Types/Journal article \|2 DataCite
336	7	_	\|a Journal Article \|b journal \|m journal \|0 PUB:(DE-HGF)16 \|s 1769601014_29843 \|2 PUB:(DE-HGF)
336	7	_	\|a ARTICLE \|2 BibTeX
336	7	_	\|a JOURNAL_ARTICLE \|2 ORCID
336	7	_	\|a Journal Article \|0 0 \|2 EndNote
520	_	_	\|a Hunger and satiety are influenced by both the amount and composition of dietary fat.This exploratory analysis examined the effects of meals enriched with different amounts of either canola oil (rich in unsaturated fatty acids) or coconut oil (rich in saturated fatty acids) on postprandial changes in subjective hunger and satiety ratings, related hormones, attention, and memory.Twenty-nine participants with an increased cardiometabolic disease risk (e.g., body mass index, 30.2 ± 2.6 kg/m2) received 4 isoenergetic (∼4200 kJ) test meals in a randomized order: high-fat meals (HFMs) (50 g) or low-fat meals (LFMs) (25 g) containing either canola or coconut oil. Hunger and satiety ratings, blood samples for ghrelin and peptide YY (PYY), and cognitive tests were conducted at fasting and over a 6-h postprandial period. The data were analyzed via linear mixed models.Lower serum ghrelin levels were observed after canola oil meals [canola compared with coconut: -27,700 (confidence interval: -40,700, -14,700) min × pg/mL] with no effect of fat amount on incremental area under the curve data [HFM compared with LFM: -9500 (-22,500, 3500) min × pg/mL]. Serum PYY concentrations were higher after HFMs [HFM compared with LFM: 8600 (2100, 15,200) min × pg/mL]. LFMs resulted in lower subjective hunger ratings compared with HFMs [HFM compared with LFM: 250 (71, 430) min × score-value].Our data indicate that predominantly the amount of dietary fat, rather than its type, affects hunger and satiety. At the hormonal level, canola oil suppressed postprandial hunger to a greater extent than coconut oil. This trial was registered at ClinicalTrials.gov (https://clinicaltrials.gov/) as NCT05208346.
536	_	_	\|a 353 - Clinical and Health Care Research (POF4-353) \|0 G:(DE-HGF)POF4-353 \|c POF4-353 \|f POF IV \|x 0
588	_	_	\|a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650	_	7	\|a attention \|2 Other
650	_	7	\|a canola oil \|2 Other
650	_	7	\|a coconut oil \|2 Other
650	_	7	\|a postprandial metabolism \|2 Other
650	_	7	\|a satiety \|2 Other
650	_	7	\|a Dietary Fats \|2 NLM Chemicals
650	_	7	\|a Fatty Acids \|2 NLM Chemicals
650	_	7	\|a Ghrelin \|2 NLM Chemicals
650	_	7	\|a Rapeseed Oil \|2 NLM Chemicals
650	_	7	\|a Coconut Oil \|0 Q9L0O73W7L \|2 NLM Chemicals
650	_	2	\|a Humans \|2 MeSH
650	_	2	\|a Female \|2 MeSH
650	_	2	\|a Male \|2 MeSH
650	_	2	\|a Hunger: drug effects \|2 MeSH
650	_	2	\|a Cross-Over Studies \|2 MeSH
650	_	2	\|a Postprandial Period \|2 MeSH
650	_	2	\|a Satiation: drug effects \|2 MeSH
650	_	2	\|a Dietary Fats: administration & dosage \|2 MeSH
650	_	2	\|a Dietary Fats: pharmacology \|2 MeSH
650	_	2	\|a Adult \|2 MeSH
650	_	2	\|a Fatty Acids: administration & dosage \|2 MeSH
650	_	2	\|a Fatty Acids: pharmacology \|2 MeSH
650	_	2	\|a Middle Aged \|2 MeSH
650	_	2	\|a Ghrelin: blood \|2 MeSH
650	_	2	\|a Attention: drug effects \|2 MeSH
650	_	2	\|a Rapeseed Oil: administration & dosage \|2 MeSH
650	_	2	\|a Coconut Oil: administration & dosage \|2 MeSH
650	_	2	\|a Cardiovascular Diseases \|2 MeSH
700	1	_	\|a Schiemann, Tim B \|b 1
700	1	_	\|a Kienēs, Hannah F \|b 2
700	1	_	\|a Wiechmann, Carolin \|b 3
700	1	_	\|a Kopp, Christina \|b 4
700	1	_	\|a Stoffel-Wagner, Birgit \|b 5
700	1	_	\|a Coenen, Martin \|b 6
700	1	_	\|a Németh, Robert \|b 7
700	1	_	\|a Wagner, Michael \|0 P:(DE-2719)2000057 \|b 8 \|u dzne
700	1	_	\|a Egert, Sarah \|b 9
773	_	_	\|a 10.1016/j.tjnut.2025.11.003 \|g Vol. 156, no. 1, p. 101232 - \|0 PERI:(DE-600)1469429-3 \|n 1 \|p 101232 \|t The journal of nutrition \|v 156 \|y 2026 \|x 0022-3166
856	4	_	\|y OpenAccess \|u https://pub.dzne.de/record/283179/files/DZNE-2026-00058.pdf
856	4	_	\|y OpenAccess \|x pdfa \|u https://pub.dzne.de/record/283179/files/DZNE-2026-00058.pdf?subformat=pdfa
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910	1	_	\|a Deutsches Zentrum für Neurodegenerative Erkrankungen \|0 I:(DE-588)1065079516 \|k DZNE \|b 8 \|6 P:(DE-2719)2000057
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Marc 21

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