000283180 001__ 283180 000283180 005__ 20260129104044.0 000283180 0247_ $$2doi$$a10.1186/s13195-025-01908-2 000283180 0247_ $$2pmid$$apmid:41350737 000283180 0247_ $$2pmc$$apmc:PMC12784552 000283180 037__ $$aDZNE-2026-00059 000283180 041__ $$aEnglish 000283180 082__ $$a610 000283180 1001_ $$00000-0001-9140-0699$$aDodich, Alessandra$$b0 000283180 245__ $$aInternational consensus for the assessment of social cognition in neurocognitive disorders: framework definition and clinical recommendations of the SIGNATURE initiative. 000283180 260__ $$aLondon$$bBioMed Central$$c2026 000283180 3367_ $$2DRIVER$$aarticle 000283180 3367_ $$2DataCite$$aOutput Types/Journal article 000283180 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1769601118_29844 000283180 3367_ $$2BibTeX$$aARTICLE 000283180 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000283180 3367_ $$00$$2EndNote$$aJournal Article 000283180 520__ $$aSocio-cognitive assessment in neurocognitive disorders (NCDs) is rare in clinical practice and no consensus exists as to a uniform operationalization of socio-cognitive measures for NCDs in memory clinics. The SIGNATURE initiative aims to optimize the use of socio-cognitive measures in memory clinics, defining expert recommendations. We report consortium guidelines for the use of socio-cognitive measures in NCDs based on available evidence from the literature and the current state of practices in memory clinics.Using a Delphi consensus method supported by a literature review and the results of an international survey, 22 specialists defined recommendations for the context of use, relevance in NCD diagnosis, priorities for future research and facilitators/obstacles of socio-cognitive assessment in major and mild NCDs.Overall, panelists recommended social cognition testing in routine diagnostic assessment to evaluate both socio-cognitive and socio-behavioral alterations. A set of clinical, methodological, implementation and external factors facilitating or hampering the use of socio-cognitive tasks was identified.This is the first focused endeavor to favor the implementation of socio-cognitive assessment, which is required by DSM-5 but seldom performed despite clear evidence of its clinical relevance for diagnosis and care. Our results provide an initial set of recommendations, refinable through the future actions of the SIGNATURE initiative. Future collaborative clinical research projects should overcome current limitations and foster the use of ecological and cross-culturally validated measures in clinics. 000283180 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0 000283180 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de 000283180 650_7 $$2Other$$aCognitive Assessment 000283180 650_7 $$2Other$$aNeurocognitive disorders 000283180 650_7 $$2Other$$aRecommendations 000283180 650_7 $$2Other$$aSocial cognition 000283180 650_2 $$2MeSH$$aHumans 000283180 650_2 $$2MeSH$$aConsensus 000283180 650_2 $$2MeSH$$aSocial Cognition 000283180 650_2 $$2MeSH$$aNeurocognitive Disorders: diagnosis 000283180 650_2 $$2MeSH$$aNeurocognitive Disorders: psychology 000283180 650_2 $$2MeSH$$aNeuropsychological Tests: standards 000283180 650_2 $$2MeSH$$aDelphi Technique 000283180 7001_ $$00009-0004-9206-6206$$aPanzavolta, Andrea$$b1 000283180 7001_ $$00000-0002-2242-6008$$aFunghi, Giulia$$b2 000283180 7001_ $$00000-0002-3450-2768$$aMeli, Claudia$$b3 000283180 7001_ $$00000-0003-3597-5097$$aFestari, Cristina$$b4 000283180 7001_ $$00000-0003-0467-358X$$aChatzikostopoulos, Thanos$$b5 000283180 7001_ $$aChicherio, Christian$$b6 000283180 7001_ $$00000-0003-4334-4404$$aClarens, Florencia$$b7 000283180 7001_ $$00000-0002-8311-0859$$ade Oliveira, Fabricio Ferreira$$b8 000283180 7001_ $$00000-0001-9702-8314$$aFilardi, Marco$$b9 000283180 7001_ $$00000-0001-6758-5101$$aIbanez, Agustin$$b10 000283180 7001_ $$aInvernizzi, Laura$$b11 000283180 7001_ $$00000-0002-4386-6045$$aLebouvier, Thibaud$$b12 000283180 7001_ $$00000-0003-0423-3242$$aLogroscino, Giancarlo$$b13 000283180 7001_ $$00000-0001-8676-6514$$aMacPherson, Sarah E$$b14 000283180 7001_ $$00000-0003-1715-6442$$aManca, Riccardo$$b15 000283180 7001_ $$00000-0003-3994-4044$$aMarra, Camillo$$b16 000283180 7001_ $$00000-0001-8162-9043$$aMatias-Guiu, Jordi A$$b17 000283180 7001_ 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