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@ARTICLE{Dodich:283180,
author = {Dodich, Alessandra and Panzavolta, Andrea and Funghi,
Giulia and Meli, Claudia and Festari, Cristina and
Chatzikostopoulos, Thanos and Chicherio, Christian and
Clarens, Florencia and de Oliveira, Fabricio Ferreira and
Filardi, Marco and Ibanez, Agustin and Invernizzi, Laura and
Lebouvier, Thibaud and Logroscino, Giancarlo and MacPherson,
Sarah E and Manca, Riccardo and Marra, Camillo and
Matias-Guiu, Jordi A and Montembeault, Maxime and Papagno,
Costanza and Pomati, Simone and Possenti, Mario and Piguet,
Olivier and Sacco, Leonardo and Schild, Ann-Katrin and
Sollberger, Marc and Tábuas-Pereira, Miguel and Tsatali,
Marianna and Tsolaki, Magda and van den Berg, Esther and
Cappa, Stefano F and Bertoux, Maxime and Kumfor, Fiona and
Van den Stock, Jan and Boccardi, Marina and Welsh-Bohmer,
Kathleen Anne and Cerami, Chiara},
collaboration = {Consortium, SIGNATURE},
othercontributors = {Agosta, Federica and Canu, Elisa and Almkvist, Ove and
Hagman, Goran and Winblad, Bengt and Altomare, Daniele and
Angioni, Davide and Annoni, Jean-Marie and Beretta, Luca and
Berres, Manfred and Bessi, Valentina and Fimm, Ingo and
Kilimann, Ingo and Bora, Emre and Brioschi-Guevara, Andrea
and Buchmann, Andreas and Gietl, Anton and Bussè, Cinzia
and Cagnin, Annachiara and Chander, Russell and Kliegel,
Matthias and Mella, Nathalie and Costa, Alfredo and
Coulangers, Camille and Ousset, Pierre-Jean and Cupidi,
Chiara and Démonet, Jean-François and Didic, Mira and Di
Lorenzo, Francesco and Dubois, Bruno and Andrade, Alan
Cronemberger and Fimm, Bruno and Galasko, Douglas and
Girtler, Nicola and Nobili, Flavio and Pardini, Matteo and
Henry, Julie and Bourdage, Renelle and Jiskoot, Lize and
Poos, Jackie and Seelaar, Haaro and Klöppel, Stefan and
Krebs, Christine and Kukull, Walter A and Levy, Richard and
Lima, Marisa and Luca, Antonella and Luzzi, Simona and
Matarrubia, Marta Fernández and Mecocci, Patrizia and
Pigliautile, Martina and Menichelli, Alina and Mitolo,
Micaela and Monsch, Andreas U and Moraitou, Despoina and
Novak, Petr and Ortiz, Miriam E and Papageorgiou, Sokratis
and Scarmeas, Nikolaos and Papatriantafyllou, John and
Plutino, Andrea and Quaranta, Davide and Ramakers, Inez and
Rossi, Stefania and Russo, Mirella and Sensi, Stefano and
Sachdev, Perminder and Salmon, David P and Sanchez, Pilar
and Schöberl, Florian and Shirk, Steven D and Toraldo,
Alessio and Venneri, Annalena and Meiberth, Dix and
Gallucci, Maurizio and Kounti, Fotini and Herrero, Silvia
Rodrigo and Marano, Pietro and Piccoli, Tommaso and Ahmed,
Samrah and Böhm, Fabiola and Schroeter, Matthias and
Vestberg, Susanna and Söntgerath, Marie and Thompson,
Jennifer and Watermeyer, Tamlyn and van der Waal,
Hendrick-Jan and Chrisman-Russell, Lucy and Morson, Silvana
and Wolski, Lucas and Dori, Renzo and Fabbo, Andrea and
Galli, Chiara and Bartels, Claudia and Geurtsen, Gert and
Baglio, Francesca and Isernia, Sara and Dogdu, Cem and Ruiu,
Elisa and Strijkert, Fijanne and Zimmermann, Nikki and
Weidner, Wendy and Briales, Helena and Pezzati, Rita and
Oksengard, Anne Rita and Bradshaw, Angela},
title = {{I}nternational consensus for the assessment of social
cognition in neurocognitive disorders: framework definition
and clinical recommendations of the {SIGNATURE} initiative.},
journal = {Alzheimer's research $\&$ therapy},
volume = {18},
number = {1},
issn = {1758-9193},
address = {London},
publisher = {BioMed Central},
reportid = {DZNE-2026-00059},
pages = {6},
year = {2026},
abstract = {Socio-cognitive assessment in neurocognitive disorders
(NCDs) is rare in clinical practice and no consensus exists
as to a uniform operationalization of socio-cognitive
measures for NCDs in memory clinics. The SIGNATURE
initiative aims to optimize the use of socio-cognitive
measures in memory clinics, defining expert recommendations.
We report consortium guidelines for the use of
socio-cognitive measures in NCDs based on available evidence
from the literature and the current state of practices in
memory clinics.Using a Delphi consensus method supported by
a literature review and the results of an international
survey, 22 specialists defined recommendations for the
context of use, relevance in NCD diagnosis, priorities for
future research and facilitators/obstacles of
socio-cognitive assessment in major and mild NCDs.Overall,
panelists recommended social cognition testing in routine
diagnostic assessment to evaluate both socio-cognitive and
socio-behavioral alterations. A set of clinical,
methodological, implementation and external factors
facilitating or hampering the use of socio-cognitive tasks
was identified.This is the first focused endeavor to favor
the implementation of socio-cognitive assessment, which is
required by DSM-5 but seldom performed despite clear
evidence of its clinical relevance for diagnosis and care.
Our results provide an initial set of recommendations,
refinable through the future actions of the SIGNATURE
initiative. Future collaborative clinical research projects
should overcome current limitations and foster the use of
ecological and cross-culturally validated measures in
clinics.},
keywords = {Humans / Consensus / Social Cognition / Neurocognitive
Disorders: diagnosis / Neurocognitive Disorders: psychology
/ Neuropsychological Tests: standards / Delphi Technique /
Cognitive Assessment (Other) / Neurocognitive disorders
(Other) / Recommendations (Other) / Social cognition
(Other)},
cin = {AG Boccardi},
ddc = {610},
cid = {I:(DE-2719)5000062},
pnm = {353 - Clinical and Health Care Research (POF4-353)},
pid = {G:(DE-HGF)POF4-353},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:41350737},
pmc = {pmc:PMC12784552},
doi = {10.1186/s13195-025-01908-2},
url = {https://pub.dzne.de/record/283180},
}