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024 7 _ |a 10.1186/s13195-025-01908-2
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037 _ _ |a DZNE-2026-00059
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Dodich, Alessandra
|0 0000-0001-9140-0699
|b 0
245 _ _ |a International consensus for the assessment of social cognition in neurocognitive disorders: framework definition and clinical recommendations of the SIGNATURE initiative.
260 _ _ |a London
|c 2026
|b BioMed Central
336 7 _ |a article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Socio-cognitive assessment in neurocognitive disorders (NCDs) is rare in clinical practice and no consensus exists as to a uniform operationalization of socio-cognitive measures for NCDs in memory clinics. The SIGNATURE initiative aims to optimize the use of socio-cognitive measures in memory clinics, defining expert recommendations. We report consortium guidelines for the use of socio-cognitive measures in NCDs based on available evidence from the literature and the current state of practices in memory clinics.Using a Delphi consensus method supported by a literature review and the results of an international survey, 22 specialists defined recommendations for the context of use, relevance in NCD diagnosis, priorities for future research and facilitators/obstacles of socio-cognitive assessment in major and mild NCDs.Overall, panelists recommended social cognition testing in routine diagnostic assessment to evaluate both socio-cognitive and socio-behavioral alterations. A set of clinical, methodological, implementation and external factors facilitating or hampering the use of socio-cognitive tasks was identified.This is the first focused endeavor to favor the implementation of socio-cognitive assessment, which is required by DSM-5 but seldom performed despite clear evidence of its clinical relevance for diagnosis and care. Our results provide an initial set of recommendations, refinable through the future actions of the SIGNATURE initiative. Future collaborative clinical research projects should overcome current limitations and foster the use of ecological and cross-culturally validated measures in clinics.
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650 _ 7 |a Cognitive Assessment
|2 Other
650 _ 7 |a Neurocognitive disorders
|2 Other
650 _ 7 |a Recommendations
|2 Other
650 _ 7 |a Social cognition
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Consensus
|2 MeSH
650 _ 2 |a Social Cognition
|2 MeSH
650 _ 2 |a Neurocognitive Disorders: diagnosis
|2 MeSH
650 _ 2 |a Neurocognitive Disorders: psychology
|2 MeSH
650 _ 2 |a Neuropsychological Tests: standards
|2 MeSH
650 _ 2 |a Delphi Technique
|2 MeSH
700 1 _ |a Panzavolta, Andrea
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700 1 _ |a Funghi, Giulia
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700 1 _ |a Meli, Claudia
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700 1 _ |a Festari, Cristina
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700 1 _ |a Chatzikostopoulos, Thanos
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700 1 _ |a Chicherio, Christian
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700 1 _ |a Clarens, Florencia
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700 1 _ |a de Oliveira, Fabricio Ferreira
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700 1 _ |a Filardi, Marco
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700 1 _ |a Ibanez, Agustin
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700 1 _ |a Invernizzi, Laura
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700 1 _ |a Lebouvier, Thibaud
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700 1 _ |a Logroscino, Giancarlo
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700 1 _ |a MacPherson, Sarah E
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700 1 _ |a Manca, Riccardo
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700 1 _ |a Marra, Camillo
|0 0000-0003-3994-4044
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700 1 _ |a Matias-Guiu, Jordi A
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700 1 _ |a Montembeault, Maxime
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700 1 _ |a Papagno, Costanza
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700 1 _ |a Pomati, Simone
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700 1 _ |a Possenti, Mario
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700 1 _ |a Piguet, Olivier
|0 0000-0002-6696-1440
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700 1 _ |a Sacco, Leonardo
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700 1 _ |a Schild, Ann-Katrin
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700 1 _ |a Sollberger, Marc
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700 1 _ |a Tábuas-Pereira, Miguel
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700 1 _ |a Tsatali, Marianna
|0 0000-0002-5972-8616
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700 1 _ |a Tsolaki, Magda
|0 0000-0002-2072-8010
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700 1 _ |a van den Berg, Esther
|0 0000-0002-8120-7366
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700 1 _ |a Cappa, Stefano F
|0 0000-0003-1003-3925
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700 1 _ |a Bertoux, Maxime
|0 0000-0002-5283-503X
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700 1 _ |a Kumfor, Fiona
|0 0000-0002-3208-075X
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700 1 _ |a Van den Stock, Jan
|0 0000-0001-5756-3195
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700 1 _ |a Boccardi, Marina
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700 1 _ |a Welsh-Bohmer, Kathleen Anne
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700 1 _ |a Cerami, Chiara
|0 0000-0003-1974-3421
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700 1 _ |a Consortium, SIGNATURE
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700 1 _ |a Agosta, Federica
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700 1 _ |a Canu, Elisa
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700 1 _ |a Almkvist, Ove
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700 1 _ |a Hagman, Goran
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700 1 _ |a Winblad, Bengt
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700 1 _ |a Altomare, Daniele
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700 1 _ |a Angioni, Davide
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700 1 _ |a Annoni, Jean-Marie
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700 1 _ |a Beretta, Luca
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700 1 _ |a Berres, Manfred
|b 47
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700 1 _ |a Bessi, Valentina
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700 1 _ |a Fimm, Ingo
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700 1 _ |a Kilimann, Ingo
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700 1 _ |a Bora, Emre
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700 1 _ |a Brioschi-Guevara, Andrea
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700 1 _ |a Buchmann, Andreas
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700 1 _ |a Gietl, Anton
|b 54
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700 1 _ |a Bussè, Cinzia
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700 1 _ |a Cagnin, Annachiara
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700 1 _ |a Chander, Russell
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700 1 _ |a Kliegel, Matthias
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700 1 _ |a Mella, Nathalie
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700 1 _ |a Costa, Alfredo
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700 1 _ |a Coulangers, Camille
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700 1 _ |a Ousset, Pierre-Jean
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700 1 _ |a Cupidi, Chiara
|b 63
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700 1 _ |a Démonet, Jean-François
|b 64
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700 1 _ |a Didic, Mira
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700 1 _ |a Di Lorenzo, Francesco
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700 1 _ |a Dubois, Bruno
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700 1 _ |a Andrade, Alan Cronemberger
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700 1 _ |a Fimm, Bruno
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700 1 _ |a Galasko, Douglas
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700 1 _ |a Girtler, Nicola
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700 1 _ |a Nobili, Flavio
|b 72
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700 1 _ |a Pardini, Matteo
|b 73
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700 1 _ |a Henry, Julie
|b 74
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700 1 _ |a Bourdage, Renelle
|b 75
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700 1 _ |a Jiskoot, Lize
|b 76
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700 1 _ |a Poos, Jackie
|b 77
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700 1 _ |a Seelaar, Haaro
|b 78
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700 1 _ |a Klöppel, Stefan
|b 79
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700 1 _ |a Krebs, Christine
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700 1 _ |a Kukull, Walter A
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700 1 _ |a Levy, Richard
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700 1 _ |a Lima, Marisa
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700 1 _ |a Luca, Antonella
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700 1 _ |a Luzzi, Simona
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700 1 _ |a Matarrubia, Marta Fernández
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700 1 _ |a Mecocci, Patrizia
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700 1 _ |a Pigliautile, Martina
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700 1 _ |a Menichelli, Alina
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700 1 _ |a Mitolo, Micaela
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700 1 _ |a Monsch, Andreas U
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700 1 _ |a Moraitou, Despoina
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700 1 _ |a Novak, Petr
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700 1 _ |a Ortiz, Miriam E
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700 1 _ |a Papageorgiou, Sokratis
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700 1 _ |a Scarmeas, Nikolaos
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700 1 _ |a Rossi, Stefania
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700 1 _ |a Schöberl, Florian
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700 1 _ |a Shirk, Steven D
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700 1 _ |a Toraldo, Alessio
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700 1 _ |a Herrero, Silvia Rodrigo
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700 1 _ |a Marano, Pietro
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700 1 _ |a Piccoli, Tommaso
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700 1 _ |a Ahmed, Samrah
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700 1 _ |a Böhm, Fabiola
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700 1 _ |a Schroeter, Matthias
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700 1 _ |a Vestberg, Susanna
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700 1 _ |a Söntgerath, Marie
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700 1 _ |a Thompson, Jennifer
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700 1 _ |a Watermeyer, Tamlyn
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700 1 _ |a van der Waal, Hendrick-Jan
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700 1 _ |a Chrisman-Russell, Lucy
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773 _ _ |a 10.1186/s13195-025-01908-2
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