TY  - JOUR
AU  - Gulban, Omer Faruk
AU  - Stirnberg, Rüdiger
AU  - Tse, Desmond Ho Yan
AU  - Pizzuti, Alessandra
AU  - Koiso, Kenshu
AU  - Archila-Melendez, Mario Eduardo
AU  - Huber, Laurentius Renzo
AU  - Bollmann, Saskia
AU  - Goebel, Rainer
AU  - Kay, Kendrick
AU  - Ivanov, Dimo
TI  - Whole-brain meso-vein imaging in living humans using fast 7-T MRI.
JO  - Science advances
VL  - 12
IS  - 2
SN  - 2375-2548
CY  - Washington, DC [u.a.]
PB  - Assoc.
M1  - DZNE-2026-00060
SP  - eaea4540
PY  - 2026
AB  - Noninvasive measurement of the human brain's angioarchitecture is essential for understanding functional neuroimaging signals, diagnosing cerebrovascular diseases, and tracking neurodegeneration. Ultrahigh-field MRI now enables mesoscopic (<0.5 millimeters) imaging, revealing vascular details previously inaccessible in vivo. Yet current approaches face two barriers: Scan times often exceed 40 minutes, and the conventional visualization methods remain limited for navigating the vasculature. Here, we present a fast whole-brain MRI protocol that resolves the venous network at 0.35 millimeters in under 7 minutes. We also introduce processing and visualization techniques that distinguish vessel types and more intuitively navigate the vasculature. These advances allow in vivo reproduction of the seminal vasculature images of Henri M. Duvernoy and provide whole-brain intracortical meso-vein maps in humans. Our methods lay the groundwork for detailed examination of vascular organization across individuals, brain regions, and cortical layers. More generally, these methods make mesoscopic imaging of angioarchitecture viable for broad neuroscientific and clinical applications.
KW  - Humans
KW  - Brain: blood supply
KW  - Brain: diagnostic imaging
KW  - Magnetic Resonance Imaging: methods
KW  - Male
KW  - Female
KW  - Adult
KW  - Neuroimaging: methods
KW  - Image Processing, Computer-Assisted
KW  - Cerebral Veins: diagnostic imaging
LB  - PUB:(DE-HGF)16
C6  - pmid:41512066
C2  - pmc:PMC12787541
DO  - DOI:10.1126/sciadv.aea4540
UR  - https://pub.dzne.de/record/283181
ER  -