%0 Conference Paper
%A Vávra, Jakub
%A Traichel, Wiebke
%A Benedet, Andrea
%A Huber, Hanna
%A Blennow, Kaj
%A Montoliu-Gaya, Laia
%A Ashton, Nicholas
%A Zetterberg, Henrik
%T Multiplex Biomarker Detection in Dried Plasma Spots: finding the best biomarker for remote blood collection
%J Alzheimer's and dementia
%V 21
%N S2
%@ 1552-5260
%M DZNE-2026-00061
%P e106925
%D 2025
%X Background: Conventional blood sampling for the testing of Alzheimer's disease (AD) biomarkers depends on stringent, time-sensitive, and temperature-dependent protocols for processing, shipping, and storage. Dry plasma spots (DPS) present a simpler, more scalable alternative for the collection, storage, and transport of blood samples and may offer an alternative sampling when access to blood volume is limited. Notably, neurodegenerative biomarkers such as p-tau, NfL, and GFAP from DPS have demonstrated a strong correlation with paired plasma on other platforms. In this pilot study, we aimed to expand on these findings by exploring a broader panel of central nervous system (CNS) biomarkers using DPS, assessing their potential for reliable and accurate detection. Method: We used the NULISA™ platform to test multiplex detection of a CNS biomarker panel (127 proteins) in DPS and matched plasma, examining plasma–DPS correlations. A discovery cohort (n = 14; mean age 71.1 ± 12.8 years; 8 females [57
%B Alzheimer’s Association International Conference
%C 27 Jul 2025 - 31 Jul 2025, Toronto (Canada)
Y2 27 Jul 2025 - 31 Jul 2025
M2 Toronto, Canada
%F PUB:(DE-HGF)1 ; PUB:(DE-HGF)16
%9 AbstractJournal Article
%R 10.1002/alz70856_106925
%U https://pub.dzne.de/record/283182