TY  - CONF
AU  - Vávra, Jakub
AU  - Traichel, Wiebke
AU  - Benedet, Andrea
AU  - Huber, Hanna
AU  - Blennow, Kaj
AU  - Montoliu-Gaya, Laia
AU  - Ashton, Nicholas
AU  - Zetterberg, Henrik
TI  - Multiplex Biomarker Detection in Dried Plasma Spots: finding the best biomarker for remote blood collection
JO  - Alzheimer's and dementia
VL  - 21
IS  - S2
SN  - 1552-5260
M1  - DZNE-2026-00061
SP  - e106925
PY  - 2025
AB  - Background: Conventional blood sampling for the testing of Alzheimer's disease (AD) biomarkers depends on stringent, time-sensitive, and temperature-dependent protocols for processing, shipping, and storage. Dry plasma spots (DPS) present a simpler, more scalable alternative for the collection, storage, and transport of blood samples and may offer an alternative sampling when access to blood volume is limited. Notably, neurodegenerative biomarkers such as p-tau, NfL, and GFAP from DPS have demonstrated a strong correlation with paired plasma on other platforms. In this pilot study, we aimed to expand on these findings by exploring a broader panel of central nervous system (CNS) biomarkers using DPS, assessing their potential for reliable and accurate detection. Method: We used the NULISA™ platform to test multiplex detection of a CNS biomarker panel (127 proteins) in DPS and matched plasma, examining plasma–DPS correlations. A discovery cohort (n = 14; mean age 71.1 ± 12.8 years; 8 females [57
T2  - Alzheimer’s Association International Conference
CY  - 27 Jul 2025 - 31 Jul 2025, Toronto (Canada)
Y2  - 27 Jul 2025 - 31 Jul 2025
M2  - Toronto, Canada
LB  - PUB:(DE-HGF)1 ; PUB:(DE-HGF)16
DO  - DOI:10.1002/alz70856_106925
UR  - https://pub.dzne.de/record/283182
ER  -