Home > In process > Activity-dependent extracellular proteolytic cascade cleaves the ECM component brevican to promote structural plasticity. > print

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037 _ _ |a DZNE-2026-00063
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Singh, Jeet Bahadur
|0 0000-0003-1738-2060
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245 _ _ |a Activity-dependent extracellular proteolytic cascade cleaves the ECM component brevican to promote structural plasticity.
260 _ _ |a [London]
|c 2026
|b Nature Publishing Group UK
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520 _ _ |a The brain's perineuronal extracellular matrix (ECM) is a crucial factor in maintaining the stability of mature brain circuitry. However, how activity-induced synaptic plasticity is achieved in the adult brain with a dense ECM is unclear. We hypothesized that neuronal activity induces cleavage of ECM, creating conditions for synaptic rearrangements. To test this hypothesis, we investigated neuronal activity-dependent proteolytic cleavage of brevican, a prototypical ECM proteoglycan, and the importance of this process for functional and structural synaptic plasticity in the rat hippocampus ex vivo. Our findings reveal that chemical long-term potentiation (cLTP) triggers rapid brevican cleavage in perisynaptic regions through the activation of an extracellular proteolytic cascade involving proprotein convertases and ADAMTS-4 and ADAMTS-5. This process requires NMDA receptor activation and involves astrocytes. Interfering with cLTP-induced brevican cleavage prevents the formation of new dendritic protrusions in CA1 but does not impact LTP induction by theta-burst stimulation of CA3-CA1 synapses. Our data reveal a mechanism of activity-dependent ECM remodeling and suggest that ECM degradation is essential for structural synaptic plasticity.
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650 _ 7 |a ADAMTS
|2 Other
650 _ 7 |a Aggrecan
|2 Other
650 _ 7 |a Dendritic Spines
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650 _ 7 |a Perineuronal Nets
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650 _ 7 |a Proprotein Convertase
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650 _ 7 |a Brevican
|2 NLM Chemicals
650 _ 7 |a Receptors, N-Methyl-D-Aspartate
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Brevican: metabolism
|2 MeSH
650 _ 2 |a Extracellular Matrix: metabolism
|2 MeSH
650 _ 2 |a Rats
|2 MeSH
650 _ 2 |a Neuronal Plasticity
|2 MeSH
650 _ 2 |a Long-Term Potentiation
|2 MeSH
650 _ 2 |a Proteolysis
|2 MeSH
650 _ 2 |a Astrocytes: metabolism
|2 MeSH
650 _ 2 |a Hippocampus: metabolism
|2 MeSH
650 _ 2 |a Hippocampus: physiology
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Synapses: metabolism
|2 MeSH
650 _ 2 |a Receptors, N-Methyl-D-Aspartate: metabolism
|2 MeSH
650 _ 2 |a Neurons: metabolism
|2 MeSH
700 1 _ |a Perelló-Amorós, Bartomeu
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700 1 _ |a Schneeberg, Jenny
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700 1 _ |a Mirzapourdelavar, Hadi
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700 1 _ |a Seidenbecher, Constanze I
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700 1 _ |a Fejtová, Anna
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700 1 _ |a Dityatev, Alexander
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700 1 _ |a Frischknecht, Renato
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773 _ _ |a 10.1038/s44319-025-00644-w
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