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001     283185
005     20260114093115.0
024 7 _ |a 10.1038/s41598-025-34951-y
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037 _ _ |a DZNE-2026-00064
041 _ _ |a English
082 _ _ |a 600
100 1 _ |a Küppers, Vincent
|b 0
245 _ _ |a Multivariate associations of motor performance, sleep quality, depressive symptoms, and grey matter volume in younger and mid-to-older adults.
260 _ _ |a [London]
|c 2026
|b Springer Nature
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520 _ _ |a Motor performance (MP) is essential for maintaining functional independence, particularly in later life. However, the relationship between MP and sleep quality, depressive symptoms, and their underlying brain substrates remains obscure. We employed four samples of younger/mid-to-older adults (n = 1,954) from the Human Connectome Project-Young Adult (HCP-YA), HCP-Aging (HCP-A), and enhanced Nathan Kline Institute-Rockland sample (eNKI-RS) to assess the replicability of our findings. Using canonical correlation analyses within a machine learning framework, we investigated the associations of sleep quality, depressive symptoms, and grey matter volume (GMV) with MP. In the combined model of the HCP-YA sample, a canonical variate of better sleep, mild, sub-clinical depressive symptoms, and altered GMV of several cortical (including precentral and fusiform gyrus), thalamus, and cerebellar brain regions was associated with a canonical variate of better MP (r = 0.2, SD = 0.05). This pattern was conceptually replicated in the young eNKI-RS sample (r = 0.25, SD = 0.13). In the HCP-A sample, a variate of better sleep quality, fewer depressive symptoms, and increased GMV was associated with a variate of MP (r = 0.18, SD = 0.1), but these findings did not replicate in the mid-to-older eNKI-RS sample (r = 0, SD = 0.12). Across all samples, variates of increased GMV were associated with variates of better MP, suggesting potential neuroanatomical underpinnings. We observed age-related variations in the multivariate associations between sleep quality, depressive symptoms, and GMV with MP.
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650 _ 7 |a Brain structure
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650 _ 7 |a Canonical correlation analysis
|2 Other
650 _ 7 |a Depressive symptoms
|2 Other
650 _ 7 |a Mental health
|2 Other
650 _ 7 |a Motor behavior
|2 Other
650 _ 7 |a Sleep quality
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Gray Matter: diagnostic imaging
|2 MeSH
650 _ 2 |a Gray Matter: pathology
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Depression: physiopathology
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Sleep Quality
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Young Adult
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Aging: physiology
|2 MeSH
650 _ 2 |a Connectome
|2 MeSH
650 _ 2 |a Brain
|2 MeSH
700 1 _ |a Bi, Hanwen
|b 1
700 1 _ |a Nicolaisen-Sobesky, Eliana
|b 2
700 1 _ |a Hoffstaedter, Felix
|b 3
700 1 _ |a Yeo, B T Thomas
|b 4
700 1 _ |a Drzezga, Alexander
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700 1 _ |a Eickhoff, Simon B
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700 1 _ |a Tahmasian, Masoud
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773 _ _ |a 10.1038/s41598-025-34951-y
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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