%0 Journal Article
%A Demir, Sebiha
%A Groteklaes, Anne
%A Dresbach, Till
%A Müller, Andreas
%A Sabir, Hemmen
%T Abnormal Amplitude-Integrated Electroencephalography and Acidosis as Key Criteria Initiating Therapeutic Hypothermia in Asphyxiated Newborns - Data From the German Hypothermia Registry.
%J Acta paediatrica
%V 115
%N 2
%@ 0001-656X
%C Oxford
%I Wiley-Blackwell
%M DZNE-2026-00066
%P 482 - 490
%D 2026
%Z ISSN 1651-2227 not unique: **2 hits**.
%X There is a wide treatment heterogeneity for asphyxiated newborn infants between hospitals in Germany. This study aimed to identify the leading entry criteria initiating therapeutic hypothermia (TH) using data from the German Hypothermia Registry.We retrospectively analyzed 262 asphyxiated newborn infants treated with TH across 74 neonatal units in Germany. Clinical and metabolic parameters and neurological assessments were recorded before the initiation of TH using a standardised electronic form in REDCap, a secure web-based platform for clinical research. Correlations between metabolic indicators (pH, base deficit, lactate) and neurological assessments, including Sarnat score, Thompson score and initial amplitude-integrated electroencephalography (aEEG) were examined.Mean gestational age was 39.4 ± 1.7 weeks. Acidosis and abnormal aEEG patterns were the most frequent criteria initiating treatment. Lower pH was strongly associated with abnormal aEEG (odds ratio 0.02, 95
%K Humans
%K Hypothermia, Induced
%K Infant, Newborn
%K Asphyxia Neonatorum: therapy
%K Asphyxia Neonatorum: complications
%K Asphyxia Neonatorum: physiopathology
%K Electroencephalography
%K Acidosis: etiology
%K Retrospective Studies
%K Registries
%K Male
%K Germany
%K Female
%K amplitude‐integrated electroencephalography (Other)
%K hypoxic–ischemic encephalopathy (Other)
%K inclusion criteria for therapeutic hypothermia (Other)
%K perinatal asphyxia (Other)
%K therapeutic hypothermia (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41162838
%2 pmc:PMC12794757
%R 10.1111/apa.70360
%U https://pub.dzne.de/record/283187