TY  - JOUR
AU  - Demir, Sebiha
AU  - Groteklaes, Anne
AU  - Dresbach, Till
AU  - Müller, Andreas
AU  - Sabir, Hemmen
TI  - Abnormal Amplitude-Integrated Electroencephalography and Acidosis as Key Criteria Initiating Therapeutic Hypothermia in Asphyxiated Newborns - Data From the German Hypothermia Registry.
JO  - Acta paediatrica
VL  - 115
IS  - 2
SN  - 0001-656X
CY  - Oxford
PB  - Wiley-Blackwell
M1  - DZNE-2026-00066
SP  - 482 - 490
PY  - 2026
N1  - ISSN 1651-2227 not unique: **2 hits**.
AB  - There is a wide treatment heterogeneity for asphyxiated newborn infants between hospitals in Germany. This study aimed to identify the leading entry criteria initiating therapeutic hypothermia (TH) using data from the German Hypothermia Registry.We retrospectively analyzed 262 asphyxiated newborn infants treated with TH across 74 neonatal units in Germany. Clinical and metabolic parameters and neurological assessments were recorded before the initiation of TH using a standardised electronic form in REDCap, a secure web-based platform for clinical research. Correlations between metabolic indicators (pH, base deficit, lactate) and neurological assessments, including Sarnat score, Thompson score and initial amplitude-integrated electroencephalography (aEEG) were examined.Mean gestational age was 39.4 ± 1.7 weeks. Acidosis and abnormal aEEG patterns were the most frequent criteria initiating treatment. Lower pH was strongly associated with abnormal aEEG (odds ratio 0.02, 95
KW  - Humans
KW  - Hypothermia, Induced
KW  - Infant, Newborn
KW  - Asphyxia Neonatorum: therapy
KW  - Asphyxia Neonatorum: complications
KW  - Asphyxia Neonatorum: physiopathology
KW  - Electroencephalography
KW  - Acidosis: etiology
KW  - Retrospective Studies
KW  - Registries
KW  - Male
KW  - Germany
KW  - Female
KW  - amplitude‐integrated electroencephalography (Other)
KW  - hypoxic–ischemic encephalopathy (Other)
KW  - inclusion criteria for therapeutic hypothermia (Other)
KW  - perinatal asphyxia (Other)
KW  - therapeutic hypothermia (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:41162838
C2  - pmc:PMC12794757
DO  - DOI:10.1111/apa.70360
UR  - https://pub.dzne.de/record/283187
ER  -