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@ARTICLE{Demir:283187,
      author       = {Demir, Sebiha and Groteklaes, Anne and Dresbach, Till and
                      Müller, Andreas and Sabir, Hemmen},
      collaboration = {Registry, German Hypothermia},
      title        = {{A}bnormal {A}mplitude-{I}ntegrated
                      {E}lectroencephalography and {A}cidosis as {K}ey {C}riteria
                      {I}nitiating {T}herapeutic {H}ypothermia in {A}sphyxiated
                      {N}ewborns - {D}ata {F}rom the {G}erman {H}ypothermia
                      {R}egistry.},
      journal      = {Acta paediatrica},
      volume       = {115},
      number       = {2},
      issn         = {0001-656X},
      address      = {Oxford},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2026-00066},
      pages        = {482 - 490},
      year         = {2026},
      note         = {ISSN 1651-2227 not unique: **2 hits**.},
      abstract     = {There is a wide treatment heterogeneity for asphyxiated
                      newborn infants between hospitals in Germany. This study
                      aimed to identify the leading entry criteria initiating
                      therapeutic hypothermia (TH) using data from the German
                      Hypothermia Registry.We retrospectively analyzed 262
                      asphyxiated newborn infants treated with TH across 74
                      neonatal units in Germany. Clinical and metabolic parameters
                      and neurological assessments were recorded before the
                      initiation of TH using a standardised electronic form in
                      REDCap, a secure web-based platform for clinical research.
                      Correlations between metabolic indicators (pH, base deficit,
                      lactate) and neurological assessments, including Sarnat
                      score, Thompson score and initial amplitude-integrated
                      electroencephalography (aEEG) were examined.Mean gestational
                      age was 39.4 ± 1.7 weeks. Acidosis and abnormal aEEG
                      patterns were the most frequent criteria initiating
                      treatment. Lower pH was strongly associated with abnormal
                      aEEG (odds ratio 0.02, $95\%$ confidence interval
                      0.002-0.19, p < 0.01). Base deficit and lactate showed
                      weaker, non-significant associations. Lower 10-min Apgar
                      scores predicted abnormal aEEG (odds ratio 0.77, $95\%$
                      confidence interval 0.69-0.87, p < 0.001).Severe acidosis
                      (pH < 7.0) was significantly associated with abnormal aEEG
                      patterns, the main determinant initiating TH. Identifying
                      abnormal aEEG patterns is essential for confirming moderate
                      to severe encephalopathy and guiding treatment.},
      keywords     = {Humans / Hypothermia, Induced / Infant, Newborn / Asphyxia
                      Neonatorum: therapy / Asphyxia Neonatorum: complications /
                      Asphyxia Neonatorum: physiopathology /
                      Electroencephalography / Acidosis: etiology / Retrospective
                      Studies / Registries / Male / Germany / Female /
                      amplitude‐integrated electroencephalography (Other) /
                      hypoxic–ischemic encephalopathy (Other) / inclusion
                      criteria for therapeutic hypothermia (Other) / perinatal
                      asphyxia (Other) / therapeutic hypothermia (Other)},
      cin          = {AG Sabir},
      ddc          = {610},
      cid          = {I:(DE-2719)5000032},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41162838},
      pmc          = {pmc:PMC12794757},
      doi          = {10.1111/apa.70360},
      url          = {https://pub.dzne.de/record/283187},
}