%0 Journal Article
%A Neumann, Timotheus Josef
%A Baz, Anna Magdalena
%A Schmidt, Elena Nicola Charlotte
%A Bendella, Zeynep
%A Clauberg, Ralf
%A Radbruch, Alexander
%A Pröbstel, Anne-Katrin
%A Bischof, Antje
%A Möhn, Nora
%A Wichtmann, Barbara Daria
%T Bildgebung neurologischer Nebenwirkungen unter Immuntherapien : Immuncheckpoint-Inhibitoren und CAR-T-Zellen  -  Imaging of neurological adverse events associated with immunotherapies : Immune checkpoint inhibitors and CAR-T cells
%J Die Radiologie
%V 66
%N 1
%@ 2731-7048
%C [Berlin]
%I Springer Medizin Verlag GmbH
%M DZNE-2026-00068
%P 59 - 66
%D 2026
%X Immune checkpoint inhibitors (ICI) and chimeric antigen receptor T‑cell (CAR-T) therapies have fundamentally transformed oncology. With their increasing use, immune-related adverse events (irAEs) have gained attention, including those affecting the nervous system.To describe the clinical and imaging characteristics of neurological immune-related adverse events (NirAEs) under ICI and CAR‑T therapy, as well as their differential diagnostic and therapeutic implications.Review of current literature on the incidence, clinical spectrum, and imaging features of NirAEs.NirAEs occur in approximately 1-6
%K Humans
%K Immune Checkpoint Inhibitors: adverse effects
%K Immune Checkpoint Inhibitors: therapeutic use
%K Immunotherapy, Adoptive: adverse effects
%K Magnetic Resonance Imaging: methods
%K Neurotoxicity Syndromes: diagnostic imaging
%K Neurotoxicity Syndromes: etiology
%K Immunotherapy: adverse effects
%K Nervous System Diseases: diagnostic imaging
%K Nervous System Diseases: chemically induced
%K Diagnosis, Differential
%K Receptors, Chimeric Antigen
%K Central and peripheral nervous system (Other)
%K ICANS (immune effector cell–associated neurotoxicity syndrome) (Other)
%K Magnetic resonance imaging (Other)
%K Neuroradiological diagnostics (Other)
%K Neurotoxicity under immunotherapy (Other)
%K Immune Checkpoint Inhibitors (NLM Chemicals)
%K Receptors, Chimeric Antigen (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41348123
%R 10.1007/s00117-025-01541-y
%U https://pub.dzne.de/record/283219