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@ARTICLE{Subkhangulova:284028,
      author       = {Subkhangulova, Aygul and Mikhaylova, Marina},
      title        = {{T}he {G}olgi apparatus: adaptations to neuronal shape and
                      functions.},
      journal      = {The EMBO journal},
      volume       = {45},
      number       = {2},
      issn         = {0261-4189},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2026-00071},
      pages        = {358 - 373},
      year         = {2026},
      abstract     = {The Golgi apparatus is the central hub of secretory and
                      endosomal pathways in a eukaryotic cell. Despite having a
                      conserved basic organization, the Golgi varies greatly in
                      structure and operation mode between different cell types,
                      ranging from dispersed cisternae in the budding yeast to the
                      ribbon of cisternae stacks in most mammalian cells. Cell
                      shape and secretory demands dictate structural and
                      functional properties of the Golgi. Neurons are a
                      particularly interesting type of secretory cells that have a
                      highly polarized architecture and a large and diverse
                      secretome. The neuronal Golgi complex evolved into an
                      elaborate set of compartmentalized organelles that process
                      and sort diverse neuronal cargos, including synaptic
                      proteins, neuropeptides, and neurotrophic factors. In this
                      review, we describe the structural adaptations of the Golgi
                      to neuronal architecture and discuss the principles of
                      neuronal cargo sorting. We also highlight structural
                      rearrangements of the neuronal Golgi in neurodegenerative
                      diseases and discuss the role of mutations in Golgi-related
                      proteins in neurodevelopment.},
      subtyp        = {Review Article},
      keywords     = {Golgi Apparatus: physiology / Golgi Apparatus: metabolism /
                      Golgi Apparatus: ultrastructure / Animals / Humans /
                      Neurons: physiology / Neurons: metabolism / Neurons:
                      cytology / Neurons: ultrastructure / Neurodegenerative
                      Diseases: metabolism / Neurodegenerative Diseases: pathology
                      / Golgi Complex (Other) / Golgi Satellites (Other) /
                      Neuronal Secretion (Other) / Trafficking (Other)},
      cin          = {AG Lichtenthaler},
      ddc          = {570},
      cid          = {I:(DE-2719)1110006},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41381732},
      pmc          = {pmc:PMC12811389},
      doi          = {10.1038/s44318-025-00658-z},
      url          = {https://pub.dzne.de/record/284028},
}