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@ARTICLE{Vlegels:284030,
author = {Vlegels, Naomi and Knuth, Nicoló L and Steiner, Konstantin
A and Zhang, Linjie and Vix, Apolline L and Moumin, Dilara
and Mirzen, Irem and Khalifeh, Nada and Forster, Charlotte
and Gesierich, Benno and Müller, Franziska and Lohse,
Philipp and Filler, Jule and Fang, Rong and Klein, Matthias
and Dimitriadis, Konstantinos and Franzmeier, Nicolai and
Liebig, Thomas and Endres, Matthias and Görtler, Michael
and Petzold, Gabor C and Wunderlich, Silke and Zerr, Inga
and Field, Thalia S and Pham, Mirko and Swartz, Richard H
and Poli, Sven and Berrouschot, Jörg and Zafar, Atif and
Schneider, Hauke and Shankar, Jai J and Aamodt, Anne Hege
and Minnerup, Jens and Mandzia, Jennifer L and Reimann,
Gernot and Psychogios, Marios-Nikos and Mundiyanapurath,
Sibu and Reich, Arno and Yeo, Leonard L L and Duering, Marco
and Reidler, Paul and Goyal, Mayank and Tymianski, Michael
and Hill, Michael D and Dichgans, Martin and Tiedt, Steffen},
collaboration = {group, DEMDAS study and investigators‡, ESCAPE-NEXT
biomarker substudy and DEMDAS study group collaborators and
investigators, ESCAPE-NEXT biomarker substudy},
othercontributors = {EndresHill, MatthiasMichael D and DuezelBarber, EmrahPhilip
A and KertiSmith, LuciaEric E and NeumannBal,
KatjaSimerpreet and MeißnerSubramanian, Julius NSuresh and
LimanPeters, Thomas GSteven and NolteCouillard, Christian
HPhilippe and WittenbergStys, TatjanaPeter and ScheitzKlein,
Jan FGary and PrüßMenon, HaraldBijoy K and SperberCoutts,
Pia SophieShelagh B and NaveDemchuk, Alexander HAndrew M and
IbarouleGoyal, Anna KufnerMayank and PetzoldKromm,
GaborJulie and BodeAlmekhlafi, FelixMohammed A and
StösserGanesh, SebastianAravind and EbrahimiBoyko,
TaranehMatthew and NordsiekChaturvedi, JuliaSurbhi and
MeißnerJoundi, Julius NRaed and BeckonertLin, NiklasKatie
and KindlerMansoor, ChristineSalman and ZerrBogiatzi,
IngaChrysi and HermannFu, PeterVivian and SchmitzHu,
MatthiasSherry and GoebelGhavami, StefanKimia and
BunckMicieli, TimothyAndrew and Schütte-SchmidtMoores,
JuliaMargaret and NuhnArabambi, SabineBabawale and
VolpersNagendra, CorinnaShashank and DechentKim, PeterDiane
and BährToussaint, MathiasLana and GörtlerMuir,
MichaelRyan and GlanzDeepak, WenzelAkshay and PerosaIgnacio,
ValentinaKatrina Hannah D and DichgansWadhwa, MartinAnkur
and WollenweberSingh, FrankNishita and GeorgakisRyckborst,
MariosKarla J and FangKenney, RongCarol and JanowitzSave,
DanielSupriya and WaegemannJambula, KarinAnitha and
TiedtCameron, SteffenCandice and WunderlichSage, SilkeKayla
and IkenbergField, BennoThalia S and BernkopfVan Gaal,
KathleenStephen C and HuberTeal, ChristianePhilip A and
PoppertBenavente, HolgerOscar R and DüringWilson,
MarcoLaura K and Araque CaballeroMann, Miguel
ÁngelSharanpal K and GesierichYip, BennoSamuel and
DewenterMurphy, AnnaColleen B and DobischTse, LauraMing Yin
Dominic and SpeckGorman, OliverJohnathan B and SpottkeGuest,
AnnikaWilliam C and StöckerZhou, TonyLily W and
BartensteinGhavami, PeterKimia and WagnerSettecase,
MichaelFabio and MacLean, Genoveva and Yip, Judy and
Villaluna, Karina and King-Azote, Princess and Ma, Carson
and Lloret, Mar and Smith, Jonathan and Lau, Lee and
Sadeghi, Mahsa and Patil, Jyoti and Gorman, Johnathon and
Plecash, Alyson and Mangat, Suneet and Heran, Manraj K S and
Redekop, Gary and Rohr, Axel and Haw, Charles and Kim,
Cha-Ney and Marangoni, Marco and Berrouschot, Jörg and
Bormann, Albrecht and Riedel-Stoll, Anett and Keilitz,
Janina and Geier, Daniela and Richter, Maria and Vierbeck,
Silvana and Voigt, Roman and Klunk, Dietrich and Krümmer,
Norma and Sternitzky, Conny and Herbst, Caroline and Pham,
Mirko and Haeusler, Karl Georg and Neugebauer, Hermann and
Hametner, Christian and Vollmuth, Christoph and Bellut,
Maximillian and Essig, Fabian and Lehrieder, Dominik and
Günthner-Lengsfeld, Thomas and Marz, Alexander and
Kollikowski, Alexander and Feick, Jorn and Vogt, Marius and
Xiong, Yanyan and Leypold, Christine and Hauck, Astrid and
Cidlinsky, Peter and Homola, György and Al-Tinawi, Fadi and
Chen, Jiechu and Vogl, Christine and Weiner, Simon and
Petzold, Gabor C and Dorn, Franziska and Reiland, Andrea and
Zülow, Stefan and Lehnen, Nils and Schmeel, Carsten and
Bode, Felix and Stösser, Sebastian and Schmidt, Sara and
Becker, Sandra and Nordsiek, Julia and Meißner, Julius and
Beckonert, Niklas and Schievelkamp, Arndt and Gronemann,
Christian and Swartz, Richard H and Southwell, Alisia and
Yu, Amy X Y and Popel, Najla and Sivakumar, Keith and
Boulos, Mark and Fitzpatrick, Tess and Liu, Anna and
Bernick, Joshua and Fatakdawala, Idris and Reiter, Stephanie
and Hawkes, Christine and Gladstone, David J and Alhamid,
May and Khosravani, Houman and Hopyan, Julia and Norouzi,
Vanessa and Costa-Alves, Aderaldo and Son, Maksim and
Enriquez, Clare Angeli and Kingston, Will and Da Costa,
Leodante and Kumar, Ashish and Kapadia, Anish and Zafar,
Atif and Kostyrko, Pawel and Bharatha, Aditya and Muccilli,
Alexandra and Marotta, Thomas R and Spears, Julian and
Pereira, Vitor and Parsons, Laura and Dowbenka, Ann and
Ramonas, Gitana and Bengzon Diestro, Jose Danilo and
Kayenat, Pakar and Schneider, Hauke and Berlis, Ansgar and
Maurer, Christoph and Behrens, Lars and Hagemann, Christian
and Gerecke, Andrea and Schaller, Anja and Yeo, Leonard L L
and Chan, Bernard P L and Sharma, Vijay and Seet, Raymond
and Gopinathan, Anil and Ong, Shao Jin and Sheldon, Ng Jin
Keat and Cunli, Yang and Wong, Lily and Chen, Jintao and
Sagayanathan, Renarebecca and Mohamad, Manohari A and Halik,
Hariz and Lim, Hui Shi and Sung, Fong Joon and Luen, Teoh
Hock and Tan, Benjamin Y Q and Mingxue, Jing and Zin, Myint
May and Keat, Chin How and Chin, Amanda X Y and Chua,
Christopher Y K and Koh, Claudia T M and Ka, Zhang and Ying,
Nicole Ng Wan and Pandya, Shivangi and Shiyang, Ng and Hui,
Goh Yi and Yeo, Joshua Y P and Jia, Megan Ng Bi and Durga,
Srees and Psychogios, Marios N and Tsogka, Ioannis and
Brehm, Alex and Sporns, Peter and Reinhardt, Julia and
Damaskinos, Michelle and Blackham, Kristine and Henn, Anne
and Walter, Katharina and Kriemler, Lilian and Dittrich,
Tolga and de Marchis, Gian Marco and Deuster, Stefanie and
Katan, Mira and Schulze-Zachau, Victor and Ngugen, Ahn and
Ntoulias, Nikolaos and Frenger, Johannes and Poli, Sven and
Tünnerhoff, Johannes and Poli, Khouloud and Mbroh, Joshua
and Adeyemi, Kamal and Gomez Exposito, Alexandra and Tieck
Fernandez, Maria Paulina and Sartor-Pfeiffer, Jennifer and
Mengel, Annerose and Barbu, Gabriel and Kalmbach, Pia and
Zeller, Julia and Ruschitzka, Sonja and Shankar, Jai Jai
Shiva and McEachern, James and Kaderali, Zul and Silvagio,
Joseph and Ghrooda, Esseddeeg and Tirvedi, Anurag and
Alcock, Susan and Kozak, Beata and Nijjar, Nazuk and Wadhwa,
Ankur and Singh, Sarbjeet and Bhairo, Audrey and Ferens,
Hatyna and Gunderson, Michael and Rear, Amber and
McLaughlin, Dawn-Lee and Huang, Beili and Singh, Nishita and
Mandzia, Jennifer L and Bullrich, Maria Bres and Fridman,
Sebastian and Khaw, Alexander V and Pandey, Sachin K and
Sposato, Luciano A and Beauchamp, Beth and Lambourn, Lindsay
and Bullrich, Maria Bres and Mai, Lauren and Alvarado
Bolanos, Alonso and Lahlouh, Amro and Umanah, Teye and
Alfajri, Abdullah and Bogiatzi, Chrysi and Casserly,
Courtney and Chan, Richard and Cumbermack, Anita Florendo
and Boulton, Mel and Majernik, Gokce Hatipoglu and Sharma,
Manas and Mayich, Michael and Yu, Yeyao and Aamodt, Anne
Hege and Skjelland, Mona and Roy, Ansar and Zamani, Mahtab
and Enriquez, Brian and Ryan, Stephen James and Sømark,
Jesper and Tveit, Lars and Skattør, Thor and Nome, Terje
and Tennøe, Bjørn and Minnerup, Jens and Stracke,
Christian-Paul and Schwindt, Wolfram and Langguth, Martina
and Schwake, Anna-Lena and Schmidt-Pogoda, Antje and Beuker,
Carolin and Hause, Stephan and Reimann, Gernot and
Gindullis, Mirco and Burg, Kerstin and Grümme, Simon and
Mecaj, Elona and Becker, Meike and Mocza, Lena and
Hagström, Inga-Tatiana and Mellage, Hanna and Kruse,
Claudia and Mundiyanapurath, Sibu and Nagel, Simon and
Ringleb, Peter and Schönenberger, Silvia and Heyse, Miriam
and Millan, Margit and Tunkl, Christine and Berberich, Anne
and Beyrle, Elisabeth and Beck, Perdita and Breunig, Silke
and Diebold, Lukas and Bonekamp, Susanne and Neureither,
Gabriele and Ungerer, Matthias and Purrucker, Jan and
Schieber, Simon and Vermehren, Philipp and Bauer, Gregor and
Tiedt, Steffen and Dichgans, Martin and Liebig, Thomas and
Dimitriadis, Konstantinos and Forbrig, Robert and D'Andrade,
Esther and Hein, Sandra and Chahli, Christine and Jaeger,
Andrea and Mühling, Melissa and Suttmann, Marie and
Kellert, Lars and Wischmann, Johannes and Denise, Birk and
Tsitos, Stergios and Eren, Ozan Emre and Lehner, Louisa
Antonella and Kopczak, Anna and Steiger, Ignaz Arnulf and
Kaffe, Maria and Schnabel, Lutz and Ben Jemaa, Imaine and
Rückel, Johannes and Brem, Christian and Fischer, David
Thomas and Johannsmann, Ole and Zimmermann, Hanna and Reich,
Arno and Schulz, Jörg B and Wiesmann, Martin and Abdelnaby,
Ramy and Blaum, Marcus and Cryns, Nina and Dafotakis, Manuel
and Ehlers, Heike and Hasan, Dimah and Weyland, Charlotte S
and Holter, Inga and Löffler, Cornelia and Matz, Oliver and
Meyer, Tareq and Minkenberg, Jan and Nikoubashman, Omid and
Ferreira De Pinho, Joao Diogo Pinhal and Reich, Arno and
Ridwan, Hani and Schiefer, Johannes and Schürmann, Kolja
and Sichtermann, Thorsten and Stockero, Andrea},
title = {{B}rain-derived tau for monitoring brain injury in acute
ischemic stroke.},
journal = {Science translational medicine},
volume = {18},
number = {832},
issn = {1946-6234},
address = {Washington, DC},
publisher = {AAAS},
reportid = {DZNE-2026-00073},
pages = {eadz1280},
year = {2026},
abstract = {A specific and accurate blood test for acute brain injury
could help monitor infarct growth in ischemic stroke and
serve as a surrogate end point in clinical trials. Using a
single-molecule detection assay, we assessed plasma
brain-derived tau (BD-tau), a marker selectively quantifying
tau protein from the central nervous system, in a
prospective cohort of 502 patients with acute ischemic
stroke with serial blood sampling from admission to day 7.
Higher BD-tau concentrations at admission were associated
with more extensive early brain injury on computed
tomography and predicted larger final infarct volumes.
BD-tau increases from admission to day 2 were related to
infarct growth. BD-tau concentrations rose until day 7 and
were higher in patients with secondary events, including
recurrent stroke. After thrombectomy, the rise of BD-tau was
smaller in patients with complete versus incomplete
recanalization. BD-tau outperformed other blood markers and
imaging metrics in predicting 90-day functional outcome
across infarct size strata and time points. In an
independent multicenter prospective cohort (N = 519), BD-tau
showed higher performance than magnetic resonance
imaging-derived final infarct volume in predicting
functional outcomes at 3, 12, and 36 months. In the
biomarker substudy of a phase 3 trial assessing nerinetide
in patients with ischemic stroke (N = 193), BD-tau showed
predictive performance comparable to the other cohorts,
mediated the relationship between recanalization and
functional outcome, and showed a $49\%$ smaller increase in
the nerinetide group versus placebo. Overall, plasma BD-tau
tracked ischemic brain injury over time, outperformed other
biomarkers in predicting functional outcomes, and identified
possible treatment responses.},
keywords = {Humans / Male / tau Proteins: blood / tau Proteins:
metabolism / Ischemic Stroke: blood / Ischemic Stroke:
complications / Ischemic Stroke: diagnostic imaging / Female
/ Aged / Biomarkers: blood / Brain: metabolism / Brain:
pathology / Middle Aged / Brain Injuries: blood / Brain
Injuries: complications / Prospective Studies / Magnetic
Resonance Imaging / Tomography, X-Ray Computed / tau
Proteins (NLM Chemicals) / Biomarkers (NLM Chemicals)},
cin = {AG Endres / AG Petzold / AG Zerr / AG Dichgans},
ddc = {500},
cid = {I:(DE-2719)1811005 / I:(DE-2719)1013020 /
I:(DE-2719)1440011-1 / I:(DE-2719)5000022},
pnm = {353 - Clinical and Health Care Research (POF4-353)},
pid = {G:(DE-HGF)POF4-353},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:41533774},
doi = {10.1126/scitranslmed.adz1280},
url = {https://pub.dzne.de/record/284030},
}
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