%0 Journal Article
%A Baldauf, Conny K
%A Poschmann, Linda
%A Edelmann-Stephan, Bärbel
%A Angenstein, Frank
%A Haage, Tobias R
%A Bhuria, Vikas
%A Philipsen, Lars
%A Berlin, Hannes
%A Dieterich, Daniela C
%A Böttcher, Martin
%A Mougiakakos, Dimitrios
%A Schraven, Burkhart
%A Fischer, Thomas
%T Integrin-dependence of extramedullary erythropoiesis in the spleen of Jak2-V617F positive myeloproliferative neoplasm in mice.
%J Experimental hematology
%V 154
%@ 0531-5573
%C Amsterdam [u.a.]
%I Elsevier Science
%M DZNE-2026-00077
%P 105340
%D 2026
%X The molecular mechanisms driving splenomegaly in myeloproliferative neoplasms (MPNs) remain poorly understood. Utilizing the Jak2-V617F knock-in mouse model, we investigated the role of β1- and β2-integrins in regulating spleen volume and spleen weight. The response to neutralizing antibodies against VLA-4 and the β2-integrin chain, as well as to isotype controls, was evaluated by serial intraindividual magnetic resonance imaging, by assessment of spleen weight and by analysis of the cellular composition of spleens. Short-term anti-VLA-4/β2-integrin treatment (applied on day 1 and evaluated at day 8) significantly reduced the spleen volume by 30
%K Animals
%K Janus Kinase 2: genetics
%K Janus Kinase 2: metabolism
%K Spleen: pathology
%K Spleen: metabolism
%K Mice
%K Myeloproliferative Disorders: genetics
%K Myeloproliferative Disorders: pathology
%K Myeloproliferative Disorders: metabolism
%K Erythropoiesis: genetics
%K Integrin alpha4beta1: genetics
%K Integrin alpha4beta1: metabolism
%K Integrin alpha4beta1: immunology
%K CD18 Antigens: genetics
%K CD18 Antigens: metabolism
%K CD18 Antigens: immunology
%K Hematopoiesis, Extramedullary
%K Integrin beta1: metabolism
%K Integrin beta1: genetics
%K Splenomegaly: genetics
%K Splenomegaly: pathology
%K Erythroblasts: pathology
%K Erythroblasts: metabolism
%K Janus Kinase 2 (NLM Chemicals)
%K Jak2 protein, mouse (NLM Chemicals)
%K Integrin alpha4beta1 (NLM Chemicals)
%K CD18 Antigens (NLM Chemicals)
%K Integrin beta1 (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41360369
%R 10.1016/j.exphem.2025.105340
%U https://pub.dzne.de/record/284042