TY  - JOUR
AU  - Baldauf, Conny K
AU  - Poschmann, Linda
AU  - Edelmann-Stephan, Bärbel
AU  - Angenstein, Frank
AU  - Haage, Tobias R
AU  - Bhuria, Vikas
AU  - Philipsen, Lars
AU  - Berlin, Hannes
AU  - Dieterich, Daniela C
AU  - Böttcher, Martin
AU  - Mougiakakos, Dimitrios
AU  - Schraven, Burkhart
AU  - Fischer, Thomas
TI  - Integrin-dependence of extramedullary erythropoiesis in the spleen of Jak2-V617F positive myeloproliferative neoplasm in mice.
JO  - Experimental hematology
VL  - 154
SN  - 0531-5573
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2026-00077
SP  - 105340
PY  - 2026
AB  - The molecular mechanisms driving splenomegaly in myeloproliferative neoplasms (MPNs) remain poorly understood. Utilizing the Jak2-V617F knock-in mouse model, we investigated the role of β1- and β2-integrins in regulating spleen volume and spleen weight. The response to neutralizing antibodies against VLA-4 and the β2-integrin chain, as well as to isotype controls, was evaluated by serial intraindividual magnetic resonance imaging, by assessment of spleen weight and by analysis of the cellular composition of spleens. Short-term anti-VLA-4/β2-integrin treatment (applied on day 1 and evaluated at day 8) significantly reduced the spleen volume by 30
KW  - Animals
KW  - Janus Kinase 2: genetics
KW  - Janus Kinase 2: metabolism
KW  - Spleen: pathology
KW  - Spleen: metabolism
KW  - Mice
KW  - Myeloproliferative Disorders: genetics
KW  - Myeloproliferative Disorders: pathology
KW  - Myeloproliferative Disorders: metabolism
KW  - Erythropoiesis: genetics
KW  - Integrin alpha4beta1: genetics
KW  - Integrin alpha4beta1: metabolism
KW  - Integrin alpha4beta1: immunology
KW  - CD18 Antigens: genetics
KW  - CD18 Antigens: metabolism
KW  - CD18 Antigens: immunology
KW  - Hematopoiesis, Extramedullary
KW  - Integrin beta1: metabolism
KW  - Integrin beta1: genetics
KW  - Splenomegaly: genetics
KW  - Splenomegaly: pathology
KW  - Erythroblasts: pathology
KW  - Erythroblasts: metabolism
KW  - Janus Kinase 2 (NLM Chemicals)
KW  - Jak2 protein, mouse (NLM Chemicals)
KW  - Integrin alpha4beta1 (NLM Chemicals)
KW  - CD18 Antigens (NLM Chemicals)
KW  - Integrin beta1 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41360369
DO  - DOI:10.1016/j.exphem.2025.105340
UR  - https://pub.dzne.de/record/284042
ER  -