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000284043 037__ $$aDZNE-2026-00078
000284043 041__ $$aEnglish
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000284043 1001_ $$aKennedy, James T$$b0
000284043 245__ $$aBrain volume trajectories in Down syndrome and autosomal dominant Alzheimer's disease.
000284043 260__ $$aHoboken, NJ$$bWiley$$c2026
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000284043 520__ $$aIt is unknown if neurodegeneration trajectories differ between Down syndrome (DS) and autosomal dominant Alzheimer's disease (ADAD), both of which are genetic forms of Alzheimer's disease (AD).We compared brain volumes in DS, ADAD, and unaffected family members serving as controls. Participants underwent magnetic resonance imaging (MRI) and amyloid positron emission tomography (PET), deriving volumetric and amyloid burden, respectively. Nonlinear associations between regional volumes and estimated years to clinical symptom onset (EYO) were evaluated using generalized additive mixed-models.Longitudinal data from 267 controls, 341 participants with DS, and 358 participants with ADAD were included, totaling 1908 scans. DS volumes were lower than ADAD and controls initially and dropped linearly. ADAD had similar volumes to controls until diverging, beginning at EYO -7. Amyloid was negatively associated with volume, with similar slopes in DS and ADAD.ADAD and DS demonstrate distinct patterns of brain volume decline prior to symptom onset despite being similarly affected by amyloid.
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000284043 650_7 $$2Other$$aMRI
000284043 650_7 $$2Other$$aamyloid
000284043 650_7 $$2Other$$avolume
000284043 650_2 $$2MeSH$$aHumans
000284043 650_2 $$2MeSH$$aDown Syndrome: pathology
000284043 650_2 $$2MeSH$$aDown Syndrome: diagnostic imaging
000284043 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000284043 650_2 $$2MeSH$$aAlzheimer Disease: diagnostic imaging
000284043 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000284043 650_2 $$2MeSH$$aMale
000284043 650_2 $$2MeSH$$aFemale
000284043 650_2 $$2MeSH$$aBrain: pathology
000284043 650_2 $$2MeSH$$aBrain: diagnostic imaging
000284043 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000284043 650_2 $$2MeSH$$aPositron-Emission Tomography
000284043 650_2 $$2MeSH$$aMiddle Aged
000284043 650_2 $$2MeSH$$aLongitudinal Studies
000284043 650_2 $$2MeSH$$aOrgan Size
000284043 650_2 $$2MeSH$$aAdult
000284043 650_2 $$2MeSH$$aDisease Progression
000284043 650_2 $$2MeSH$$aAged
000284043 693__ $$0EXP:(DE-2719)DIAN-20090101$$5EXP:(DE-2719)DIAN-20090101$$eLongitudinal Study on Dominantly Inherited Alzheimer's Disease$$x0
000284043 7001_ $$aWisch, Julie K$$b1
000284043 7001_ $$aBoerwinkle, Anna H$$b2
000284043 7001_ $$aMillar, Peter R$$b3
000284043 7001_ $$aMcKay, Nicole S$$b4
000284043 7001_ $$aBrickman, Adam M$$b5
000284043 7001_ $$aChhatwal, Jasmeer P$$b6
000284043 7001_ $$aMendez, Patricio Chrem$$b7
000284043 7001_ $$aChristian, Bradley T$$b8
000284043 7001_ $$aCohen, Anne$$b9
000284043 7001_ $$aCruchaga, Carlos$$b10
000284043 7001_ $$aDaniels, Alisha$$b11
000284043 7001_ $$aFlores, Shaney$$b12
000284043 7001_ $$aHanden, Benjamin L$$b13
000284043 7001_ $$aHartley, Sigan L$$b14
000284043 7001_ $$aHead, Elizabeth$$b15
000284043 7001_ $$aIbanez, Laura$$b16
000284043 7001_ $$aKrisnsky-McHale, Sharon J$$b17
000284043 7001_ $$ala Fougere, Christian$$b18
000284043 7001_ $$aLai, Florence$$b19
000284043 7001_ $$aLaymon, Charles M$$b20
000284043 7001_ $$aLee, Joseph H$$b21
000284043 7001_ $$0P:(DE-HGF)0$$aLee, Jae-Hong$$b22
000284043 7001_ $$0P:(DE-2719)2811659$$aLevin, Johannes$$b23$$udzne
000284043 7001_ $$aLlibre-Guerra, Jorge$$b24
000284043 7001_ $$aAguillon, David F$$b25
000284043 7001_ $$aLott, Ira T$$b26
000284043 7001_ $$aMapstone, Mark$$b27
000284043 7001_ $$aMcDade, Eric$$b28
000284043 7001_ $$aMorris, John$$b29
000284043 7001_ $$aO'Bryant, Sid E$$b30
000284043 7001_ $$aPrice, Julie C$$b31
000284043 7001_ $$aRafii, Michael S$$b32
000284043 7001_ $$aRoh, Jee Hoon$$b33
000284043 7001_ $$aRosas, H Diana$$b34
000284043 7001_ $$aSchupf, Nicole$$b35
000284043 7001_ $$aSupnet-Bell, Charlene$$b36
000284043 7001_ $$aXiong, Chengjie$$b37
000284043 7001_ $$aZaman, Shahid$$b38
000284043 7001_ $$aBenzinger, Tammie L S$$b39
000284043 7001_ $$aGordon, Brian A$$b40
000284043 7001_ $$aAnces, Beau M$$b41
000284043 7001_ $$aAlzheimer's Brain Consortium - Down Syndrome$$b42
000284043 7001_ $$aNetwork, the Dominantly Inherited Alzheimer's$$b43$$eCollaboration Author
000284043 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.71103$$gVol. 22, no. 1, p. e71103$$n1$$pe71103$$tAlzheimer's and dementia$$v22$$x1552-5260$$y2026
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