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@ARTICLE{Kennedy:284043,
      author       = {Kennedy, James T and Wisch, Julie K and Boerwinkle, Anna H
                      and Millar, Peter R and McKay, Nicole S and Brickman, Adam M
                      and Chhatwal, Jasmeer P and Mendez, Patricio Chrem and
                      Christian, Bradley T and Cohen, Anne and Cruchaga, Carlos
                      and Daniels, Alisha and Flores, Shaney and Handen, Benjamin
                      L and Hartley, Sigan L and Head, Elizabeth and Ibanez, Laura
                      and Krisnsky-McHale, Sharon J and la Fougere, Christian and
                      Lai, Florence and Laymon, Charles M and Lee, Joseph H and
                      Lee, Jae-Hong and Levin, Johannes and Llibre-Guerra, Jorge
                      and Aguillon, David F and Lott, Ira T and Mapstone, Mark and
                      McDade, Eric and Morris, John and O'Bryant, Sid E and Price,
                      Julie C and Rafii, Michael S and Roh, Jee Hoon and Rosas, H
                      Diana and Schupf, Nicole and Supnet-Bell, Charlene and
                      Xiong, Chengjie and Zaman, Shahid and Benzinger, Tammie L S
                      and Gordon, Brian A and Ances, Beau M and Alzheimer's Brain
                      Consortium - Down Syndrome},
      collaboration = {Network, the Dominantly Inherited Alzheimer's},
      title        = {{B}rain volume trajectories in {D}own syndrome and
                      autosomal dominant {A}lzheimer's disease.},
      journal      = {Alzheimer's and dementia},
      volume       = {22},
      number       = {1},
      issn         = {1552-5260},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DZNE-2026-00078},
      pages        = {e71103},
      year         = {2026},
      abstract     = {It is unknown if neurodegeneration trajectories differ
                      between Down syndrome (DS) and autosomal dominant
                      Alzheimer's disease (ADAD), both of which are genetic forms
                      of Alzheimer's disease (AD).We compared brain volumes in DS,
                      ADAD, and unaffected family members serving as controls.
                      Participants underwent magnetic resonance imaging (MRI) and
                      amyloid positron emission tomography (PET), deriving
                      volumetric and amyloid burden, respectively. Nonlinear
                      associations between regional volumes and estimated years to
                      clinical symptom onset (EYO) were evaluated using
                      generalized additive mixed-models.Longitudinal data from 267
                      controls, 341 participants with DS, and 358 participants
                      with ADAD were included, totaling 1908 scans. DS volumes
                      were lower than ADAD and controls initially and dropped
                      linearly. ADAD had similar volumes to controls until
                      diverging, beginning at EYO -7. Amyloid was negatively
                      associated with volume, with similar slopes in DS and
                      ADAD.ADAD and DS demonstrate distinct patterns of brain
                      volume decline prior to symptom onset despite being
                      similarly affected by amyloid.},
      keywords     = {Humans / Down Syndrome: pathology / Down Syndrome:
                      diagnostic imaging / Alzheimer Disease: pathology /
                      Alzheimer Disease: diagnostic imaging / Alzheimer Disease:
                      genetics / Male / Female / Brain: pathology / Brain:
                      diagnostic imaging / Magnetic Resonance Imaging /
                      Positron-Emission Tomography / Middle Aged / Longitudinal
                      Studies / Organ Size / Adult / Disease Progression / Aged /
                      MRI (Other) / amyloid (Other) / volume (Other)},
      cin          = {Clinical Research (Munich) / AG Levin},
      ddc          = {610},
      cid          = {I:(DE-2719)1111015 / I:(DE-2719)1111016},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      experiment   = {EXP:(DE-2719)DIAN-20090101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41549404},
      doi          = {10.1002/alz.71103},
      url          = {https://pub.dzne.de/record/284043},
}