guest ::
| Home > In process > Secondary obsessive-compulsive syndromes: a systematic literature review resulting in 228 suspected cases. > print |
| Home > In process > Secondary obsessive-compulsive syndromes: a systematic literature review resulting in 228 suspected cases. > print |
| 001 | 284044 | ||
| 005 | 20260122091732.0 | ||
| 024 | 7 | _ | |a 10.1038/s41380-025-03395-1 |2 doi |
| 024 | 7 | _ | |a pmid:41436581 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC12815680 |2 pmc |
| 024 | 7 | _ | |a 1359-4184 |2 ISSN |
| 024 | 7 | _ | |a 1476-5578 |2 ISSN |
| 037 | _ | _ | |a DZNE-2026-00079 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Runge, Kimon |0 0000-0002-0263-4360 |b 0 |
| 245 | _ | _ | |a Secondary obsessive-compulsive syndromes: a systematic literature review resulting in 228 suspected cases. |
| 260 | _ | _ | |a [London] |c 2026 |b Springer Nature |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1769069665_9322 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Secondary forms of obsessive-compulsive disorder (OCD) have clear underlying organic causes and are recognized as distinct nosological entities in the latest international classification systems. This study aims to provide a systematic overview of published cases of suspected secondary obsessive-compulsive syndromes. A systematic literature search of PubMed, Embase, Web of Science, and PsycINFO was conducted oriented on PRISMA criteria. Cases from case studies/series of patients with suspected secondary obsessive-compulsive syndromes and/or secondary obsessive-compulsive symptoms were included. Cases of obsessive-compulsive symptoms due to pediatric acute-onset neuropsychiatric syndrome (PANS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) were excluded. Overall, 228 cases of suspected secondary obsessive-compulsive syndromes were identified from 189 publications. Causal factors included brain lesions (25.4%), genetic syndromes (24.1%), head trauma (12.3%), autoimmune-inflammatory processes (11.8%), tumors (8.3%), neurodegeneration (7.5%), seizures (4.8%), pathogens (3.9%), metabolic processes (1.3%), or other reasons (0.4%). The age of the affected patients varied considerably (mean 37.3 ± 21.2 years, range 4-94 years, n = 226). Diagnostic abnormalities were identified through brain imaging (magnetic resonance imaging/computer tomography) in 66.2% of the sample and via blood analysis in 23.9%. In cases reporting the regions of the brain involvement, frontal lobe (34.3%) and the basal ganglia (26.5%) were mostly affected. The findings highlight a variety of suspected causes of secondary obsessive-compulsive syndromes, most frequently brain lesions, genetic syndromes, head trauma, and autoimmune-inflammatory processes. Identifying secondary obsessive-compulsive symptoms informed personalized therapies in a subgroup of published cases. |
| 536 | _ | _ | |a 353 - Clinical and Health Care Research (POF4-353) |0 G:(DE-HGF)POF4-353 |c POF4-353 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 2 | |a Adolescent |2 MeSH |
| 650 | _ | 2 | |a Adult |2 MeSH |
| 650 | _ | 2 | |a Child |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Autoimmune Diseases: complications |2 MeSH |
| 650 | _ | 2 | |a Brain |2 MeSH |
| 650 | _ | 2 | |a Obsessive-Compulsive Disorder: etiology |2 MeSH |
| 650 | _ | 2 | |a Obsessive-Compulsive Disorder: diagnosis |2 MeSH |
| 650 | _ | 2 | |a Streptococcal Infections |2 MeSH |
| 700 | 1 | _ | |a Feige, Bernd |0 0000-0002-9436-1258 |b 1 |
| 700 | 1 | _ | |a Schiele, Miriam A |b 2 |
| 700 | 1 | _ | |a von Zedtwitz, Katharina |b 3 |
| 700 | 1 | _ | |a Maier, Alexander |b 4 |
| 700 | 1 | _ | |a Stöcker, Nils |b 5 |
| 700 | 1 | _ | |a Dressle, Raphael J |0 0000-0001-9408-5196 |b 6 |
| 700 | 1 | _ | |a Baldermann, Juan C |0 0000-0001-5851-9268 |b 7 |
| 700 | 1 | _ | |a Maier, Simon J |b 8 |
| 700 | 1 | _ | |a Nickel, Kathrin |0 0000-0001-9863-317X |b 9 |
| 700 | 1 | _ | |a Prüss, Harald |0 P:(DE-2719)2810931 |b 10 |
| 700 | 1 | _ | |a Coenen, Volker Arnd |0 P:(DE-2719)9000878 |b 11 |
| 700 | 1 | _ | |a Voderholzer, Ulrich |b 12 |
| 700 | 1 | _ | |a Domschke, Katharina |0 0000-0002-2550-9132 |b 13 |
| 700 | 1 | _ | |a Tebartz van Elst, Ludger |0 0000-0002-2274-5447 |b 14 |
| 700 | 1 | _ | |a Endres, Dominique |0 0000-0001-7322-1195 |b 15 |
| 773 | _ | _ | |a 10.1038/s41380-025-03395-1 |g Vol. 31, no. 2, p. 1121 - 1131 |0 PERI:(DE-600)1502531-7 |n 2 |p 1121 - 1131 |t Molecular psychiatry |v 31 |y 2026 |x 1359-4184 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/284044/files/DZNE-2026-00079.pdf |y Restricted |
| 856 | 4 | _ | |u https://pub.dzne.de/record/284044/files/DZNE-2026-00079.pdf?subformat=pdfa |x pdfa |y Restricted |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 10 |6 P:(DE-2719)2810931 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-353 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Clinical and Health Care Research |x 0 |
| 915 | _ | _ | |a DEAL Springer |0 StatID:(DE-HGF)3002 |2 StatID |d 2024-12-18 |w ger |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2024-12-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2024-12-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2024-12-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2024-12-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2024-12-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2024-12-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2024-12-18 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2024-12-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2024-12-18 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b MOL PSYCHIATR : 2022 |d 2024-12-18 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2024-12-18 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2024-12-18 |
| 915 | _ | _ | |a IF >= 10 |0 StatID:(DE-HGF)9910 |2 StatID |b MOL PSYCHIATR : 2022 |d 2024-12-18 |
| 920 | 1 | _ | |0 I:(DE-2719)1810003 |k AG Prüß |l Autoimmune Encephalopathies |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a EDITORS |
| 980 | _ | _ | |a VDBINPRINT |
| 980 | _ | _ | |a I:(DE-2719)1810003 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|