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Open-SESAME

OPENing biological barriers using Shell-Engineered Shape-Adaptable Microbubble Enhancers

Grant period2025-10-01 - 2027-03-31
Funding bodyEuropean Union
 CORDIS
Call numberERC-2025-POC
Grant number101247604
IdentifierG:(EU-Grant)101247604

Note: Microbubles unlocking next-gen drug delivery. Delivering drugs effectively across biological barriers, such as the blood-brain barrier or dense tumour tissue, remains a challenge. Therapies may fail because they cannot reach their intended targets in sufficient doses without causing harmful side effects. Ultrasound-responsive microbubbles can work to temporarily open pathways for drugs to penetrate otherwise resistant tissues. The ERC-funded Open-SESAME project is developing a modular microbubble platform. Researchers will refine scalable synthesis methods, test performance in brain and tumour models, and strengthen intellectual property for future commercialisation. By combining preclinical validation with market analysis, Open-SESAME aims to deliver an investor-ready plan that could transform treatment for patients with high unmet medical needs.
   

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 Record created 2026-01-22, last modified 2026-01-22
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