TY  - JOUR
AU  - Secchim Ribeiro, Lucas
AU  - Marques, Rafael Elias
AU  - Jesus, Amélia Maria Ribeiro de
AU  - Almeida, Roque Pacheco de
AU  - Teixeira, Mauro Martins
TI  - Zika crisis in Brazil: challenges in research and development
JO  - Current opinion in virology
VL  - 18
SN  - 1879-6257
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DZNE-2026-00100
SP  - 76 - 81
PY  - 2016
AB  - Infection with the Zika virus (ZIKV) usually causes a mild acute illness, but two major severe syndromes have been described during the epidemic in Brazil: microcephaly and the Guillain-Barré Syndrome. There is now much evidence to show that ZIKV can infect and damage neuronal cells in vitro. In experimental animals, ZIKV has significant neurotropism and can cause brain damage. At present, diagnosis is still a challenge in the field and there is no treatment available. Another major challenge is that one must devise therapies for pregnant women, at all stages of pregnancy. Devising adequate treatment for ZIKV infections represents a challenge that will only be met by the joint effort of the research community.
KW  - Animals
KW  - Brazil
KW  - Disease Models, Animal
KW  - Female
KW  - Guillain-Barre Syndrome: virology
KW  - Humans
KW  - Infant, Newborn
KW  - Mice
KW  - Microcephaly: virology
KW  - Pregnancy
KW  - Primates
KW  - Zika Virus: isolation & purification
KW  - Zika Virus: pathogenicity
KW  - Zika Virus Infection: drug therapy
KW  - Zika Virus Infection: immunology
KW  - Zika Virus Infection: therapy
KW  - Zika Virus Infection: virology
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1016/j.coviro.2016.04.002
UR  - https://pub.dzne.de/record/284092
ER  -