Journal Article (Review Article)

DZNE-2026-00100

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Zika crisis in Brazil: challenges in research and development

Secchim Ribeiro, L.Extern* ; Marques, R. E. ; Jesus, A. M. R. d. ; Almeida, R. P. d. ; Teixeira, M. M.

2016
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.coviro.2016.04.002

Abstract: Infection with the Zika virus (ZIKV) usually causes a mild acute illness, but two major severe syndromes have been described during the epidemic in Brazil: microcephaly and the Guillain-Barré Syndrome. There is now much evidence to show that ZIKV can infect and damage neuronal cells in vitro. In experimental animals, ZIKV has significant neurotropism and can cause brain damage. At present, diagnosis is still a challenge in the field and there is no treatment available. Another major challenge is that one must devise therapies for pregnant women, at all stages of pregnancy. Devising adequate treatment for ZIKV infections represents a challenge that will only be met by the joint effort of the research community.

Keyword(s): Animals (MeSH) ; Brazil (MeSH) ; Disease Models, Animal (MeSH) ; Female (MeSH) ; Guillain-Barre Syndrome: virology (MeSH) ; Humans (MeSH) ; Infant, Newborn (MeSH) ; Mice (MeSH) ; Microcephaly: virology (MeSH) ; Pregnancy (MeSH) ; Primates (MeSH) ; Zika Virus: isolation & purification (MeSH) ; Zika Virus: pathogenicity (MeSH) ; Zika Virus Infection: drug therapy (MeSH) ; Zika Virus Infection: immunology (MeSH) ; Zika Virus Infection: therapy (MeSH) ; Zika Virus Infection: virology (MeSH)

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Research Program(s):

1. 899 - ohne Topic (POF4-899) (POF4-899)

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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