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@ARTICLE{SecchimRibeiro:284092,
      author       = {Secchim Ribeiro, Lucas and Marques, Rafael Elias and Jesus,
                      Amélia Maria Ribeiro de and Almeida, Roque Pacheco de and
                      Teixeira, Mauro Martins},
      title        = {{Z}ika crisis in {B}razil: challenges in research and
                      development},
      journal      = {Current opinion in virology},
      volume       = {18},
      issn         = {1879-6257},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2026-00100},
      pages        = {76 - 81},
      year         = {2016},
      abstract     = {Infection with the Zika virus (ZIKV) usually causes a mild
                      acute illness, but two major severe syndromes have been
                      described during the epidemic in Brazil: microcephaly and
                      the Guillain-Barré Syndrome. There is now much evidence to
                      show that ZIKV can infect and damage neuronal cells in
                      vitro. In experimental animals, ZIKV has significant
                      neurotropism and can cause brain damage. At present,
                      diagnosis is still a challenge in the field and there is no
                      treatment available. Another major challenge is that one
                      must devise therapies for pregnant women, at all stages of
                      pregnancy. Devising adequate treatment for ZIKV infections
                      represents a challenge that will only be met by the joint
                      effort of the research community.},
      subtyp        = {Review Article},
      keywords     = {Animals / Brazil / Disease Models, Animal / Female /
                      Guillain-Barre Syndrome: virology / Humans / Infant, Newborn
                      / Mice / Microcephaly: virology / Pregnancy / Primates /
                      Zika Virus: isolation $\&$ purification / Zika Virus:
                      pathogenicity / Zika Virus Infection: drug therapy / Zika
                      Virus Infection: immunology / Zika Virus Infection: therapy
                      / Zika Virus Infection: virology},
      ddc          = {610},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.coviro.2016.04.002},
      url          = {https://pub.dzne.de/record/284092},
}