TY  - JOUR
AU  - Bräuer, Stefan
AU  - Sondermann, Verena
AU  - Schniewind, Inaki
AU  - Hähnel, Tom
AU  - Dinter, Elisabeth
AU  - Kleineidam, Luca
AU  - Stark, Melina
AU  - Schmid, Matthias
AU  - Sodenkamp, Sebastian
AU  - Laske, Christoph
AU  - Spruth, Eike
AU  - Priller, Josef
AU  - Janowitz, Daniel
AU  - Bürger, Katharina
AU  - Kilimann, Ingo
AU  - Teipel, Stefan
AU  - Storch, Alexander
AU  - Hansen, Niels
AU  - Wiltfang, Jens
AU  - Glanz, Wenzel
AU  - Düzel, Emrah
AU  - Preis, Lukas
AU  - Peters, Oliver
AU  - Hellmann-Regen, Julian
AU  - Wagner, Michael
AU  - Bernhardt, Alexander Maximilian
AU  - Levin, Johannes
AU  - Petzold, Gabor
AU  - Kronmüller, Marie
AU  - Gamez, Anna
AU  - Spottke, Annika
AU  - Brosseron, Frederic
AU  - Rostamzadeh, Ayda
AU  - Jessen, Frank
AU  - Hermann, Andreas
AU  - Fliessbach, Klaus
AU  - Schneider, Anja
AU  - Falkenburger, Björn H
TI  - Alpha-synuclein quantitative seed amplification assay predicts conversion to dementia.
JO  - Alzheimer's and dementia
VL  - 22
IS  - 1
SN  - 1552-5260
CY  - Hoboken, NJ
PB  - Wiley
M1  - DZNE-2026-00110
SP  - e71167
PY  - 2026
AB  - The alpha-synuclein seed amplification assay (SAA) has shown excellent performance in the detection of Lewy body pathology in cerebrospinal fluid (CSF). Lewy body pathology is prognostically relevant in patients at risk for dementia. Current assays only provide binary results, so there is a need to quantify the extent of pathology in living patients.In addition to the 'standard' SAA, we developed a quantitative SAA (qnSAA) and measured 432 CSF samples (216 baseline-follow-up pairs).qnSAA results correlated with cognitive performance. Seventy-five percent of participants with fast qnSAA kinetics converted to dementia in the observed interval. Overall, participants with fast qnSAA kinetics accounted for 27.3
KW  - Humans
KW  - alpha-Synuclein: cerebrospinal fluid
KW  - Male
KW  - Female
KW  - Dementia: cerebrospinal fluid
KW  - Dementia: diagnosis
KW  - Aged
KW  - Disease Progression
KW  - Biomarkers: cerebrospinal fluid
KW  - Aged, 80 and over
KW  - Lewy Body Disease: cerebrospinal fluid
KW  - Prognosis
KW  - Cohort Studies
KW  - Alzheimer´s disease (Other)
KW  - Lewy body (Other)
KW  - alpha‐synuclein (Other)
KW  - dementia (Other)
KW  - real‐time quaking‐induced conversion (Other)
KW  - seed amplification assay (Other)
KW  - alpha-Synuclein (NLM Chemicals)
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:41572624
C2  - pmc:PMC12828062
DO  - DOI:10.1002/alz.71167
UR  - https://pub.dzne.de/record/284335
ER  -