%0 Journal Article
%A Marth, Lena
%A Martinez-Murcia, Francisco J
%A Górriz-Sáez, Juan-Manuel
%A Denecke, Jannis
%A Ewers, Michael
%A Prix, Catharina
%A Stockbauer, Anna Christina
%A Bernhardt, Alexander Maximilian
%A Wagemann, Olivia
%A Wlasich, Elisabeth
%A Kustermann, Julia
%A Peters, Oliver
%A Hellmann-Regen, Julian
%A Droste Zu Senden, Louise
%A Priller, Josef
%A Spruth, Eike Jakob
%A Spottke, Annika
%A Asperger, Hannah
%A Schroeck, Friederike
%A Gamez, Anna
%A Schneider, Anja
%A Fliessbach, Klaus
%A Dinter, Elisabeth
%A Linn, Jennifer
%A Günther, Rene
%A Wiltfang, Jens
%A Schott, Björn H
%A Bähr, Mathias
%A Zerr, Inga
%A Flöel, Agnes
%A Malinowski, Robert
%A Buerger, Katharina
%A Janowitz, Daniel
%A Duzel, Emrah
%A Glanz, Wenzel
%A Lüsebrink, Falk
%A Teipel, Stefan J
%A Kilimann, Ingo
%A Prudlo, Johannes
%A Hermann, Andreas
%A Synofzik, Matthis
%A Mengel, David
%A Beichert, Lukas
%A Müller, Doreen
%A Petzold, Gabor C
%A Yakupov, Renat
%A Hetzer, Stefan
%A Dechent, Peter
%A Scheffler, Klaus
%A Schönecker, Sonja
%A Levin, Johannes
%T Patterns and Trajectories of Behavioral and Neuropsychiatric Symptoms in Frontotemporal Dementia and Primary Progressive Aphasia.
%J Neurology
%V 106
%N 4
%@ 0028-3878
%C Philadelphia, Pa.
%I Wolters Kluwer
%M DZNE-2026-00117
%P e214510
%D 2026
%X Behavioral and neuropsychiatric symptoms are common in frontotemporal dementia (FTD) and primary progressive aphasia (PPA). However, little is known about their patterns, time course, and association with brain atrophy. We, therefore, aimed to describe behavioral and neuropsychiatric phenotypes in patients with FTD and PPA, leveraging a hypothesis-free/data-driven approach.We included participants diagnosed with behavioral variant FTD (bvFTD) or PPA according to Rascovsky and Gorno-Tempini criteria from the German Center for Neurodegenerative Diseases Clinical Registry Study of Neurodegenerative Diseases-FTD prospective multicenter observational cohort study. Symptoms were assessed using the Neuropsychiatric Inventory-Questionnaire. Principal component analysis (PCA) was used to delineate symptom groups. Subsequently, frequency and severity across diagnostic groups were examined. We applied linear mixed-effects models to describe the longitudinal evolution of symptoms. Associations with MRI-assessed atrophy were investigated using linear regression models.A total of 314 patients (42.4
%K Humans
%K Male
%K Female
%K Aphasia, Primary Progressive: psychology
%K Aphasia, Primary Progressive: diagnostic imaging
%K Aphasia, Primary Progressive: pathology
%K Aphasia, Primary Progressive: complications
%K Aphasia, Primary Progressive: physiopathology
%K Frontotemporal Dementia: psychology
%K Frontotemporal Dementia: diagnostic imaging
%K Frontotemporal Dementia: pathology
%K Frontotemporal Dementia: complications
%K Frontotemporal Dementia: physiopathology
%K Aged
%K Middle Aged
%K Magnetic Resonance Imaging
%K Atrophy: pathology
%K Neuropsychological Tests
%K Prospective Studies
%K Brain: pathology
%K Brain: diagnostic imaging
%K Disease Progression
%K Cohort Studies
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41592266
%R 10.1212/WNL.0000000000214510
%U https://pub.dzne.de/record/284346