TY  - JOUR
AU  - Marth, Lena
AU  - Martinez-Murcia, Francisco J
AU  - Górriz-Sáez, Juan-Manuel
AU  - Denecke, Jannis
AU  - Ewers, Michael
AU  - Prix, Catharina
AU  - Stockbauer, Anna Christina
AU  - Bernhardt, Alexander Maximilian
AU  - Wagemann, Olivia
AU  - Wlasich, Elisabeth
AU  - Kustermann, Julia
AU  - Peters, Oliver
AU  - Hellmann-Regen, Julian
AU  - Droste Zu Senden, Louise
AU  - Priller, Josef
AU  - Spruth, Eike Jakob
AU  - Spottke, Annika
AU  - Asperger, Hannah
AU  - Schroeck, Friederike
AU  - Gamez, Anna
AU  - Schneider, Anja
AU  - Fliessbach, Klaus
AU  - Dinter, Elisabeth
AU  - Linn, Jennifer
AU  - Günther, Rene
AU  - Wiltfang, Jens
AU  - Schott, Björn H
AU  - Bähr, Mathias
AU  - Zerr, Inga
AU  - Flöel, Agnes
AU  - Malinowski, Robert
AU  - Buerger, Katharina
AU  - Janowitz, Daniel
AU  - Duzel, Emrah
AU  - Glanz, Wenzel
AU  - Lüsebrink, Falk
AU  - Teipel, Stefan J
AU  - Kilimann, Ingo
AU  - Prudlo, Johannes
AU  - Hermann, Andreas
AU  - Synofzik, Matthis
AU  - Mengel, David
AU  - Beichert, Lukas
AU  - Müller, Doreen
AU  - Petzold, Gabor C
AU  - Yakupov, Renat
AU  - Hetzer, Stefan
AU  - Dechent, Peter
AU  - Scheffler, Klaus
AU  - Schönecker, Sonja
AU  - Levin, Johannes
TI  - Patterns and Trajectories of Behavioral and Neuropsychiatric Symptoms in Frontotemporal Dementia and Primary Progressive Aphasia.
JO  - Neurology
VL  - 106
IS  - 4
SN  - 0028-3878
CY  - Philadelphia, Pa.
PB  - Wolters Kluwer
M1  - DZNE-2026-00117
SP  - e214510
PY  - 2026
AB  - Behavioral and neuropsychiatric symptoms are common in frontotemporal dementia (FTD) and primary progressive aphasia (PPA). However, little is known about their patterns, time course, and association with brain atrophy. We, therefore, aimed to describe behavioral and neuropsychiatric phenotypes in patients with FTD and PPA, leveraging a hypothesis-free/data-driven approach.We included participants diagnosed with behavioral variant FTD (bvFTD) or PPA according to Rascovsky and Gorno-Tempini criteria from the German Center for Neurodegenerative Diseases Clinical Registry Study of Neurodegenerative Diseases-FTD prospective multicenter observational cohort study. Symptoms were assessed using the Neuropsychiatric Inventory-Questionnaire. Principal component analysis (PCA) was used to delineate symptom groups. Subsequently, frequency and severity across diagnostic groups were examined. We applied linear mixed-effects models to describe the longitudinal evolution of symptoms. Associations with MRI-assessed atrophy were investigated using linear regression models.A total of 314 patients (42.4
KW  - Humans
KW  - Male
KW  - Female
KW  - Aphasia, Primary Progressive: psychology
KW  - Aphasia, Primary Progressive: diagnostic imaging
KW  - Aphasia, Primary Progressive: pathology
KW  - Aphasia, Primary Progressive: complications
KW  - Aphasia, Primary Progressive: physiopathology
KW  - Frontotemporal Dementia: psychology
KW  - Frontotemporal Dementia: diagnostic imaging
KW  - Frontotemporal Dementia: pathology
KW  - Frontotemporal Dementia: complications
KW  - Frontotemporal Dementia: physiopathology
KW  - Aged
KW  - Middle Aged
KW  - Magnetic Resonance Imaging
KW  - Atrophy: pathology
KW  - Neuropsychological Tests
KW  - Prospective Studies
KW  - Brain: pathology
KW  - Brain: diagnostic imaging
KW  - Disease Progression
KW  - Cohort Studies
LB  - PUB:(DE-HGF)16
C6  - pmid:41592266
DO  - DOI:10.1212/WNL.0000000000214510
UR  - https://pub.dzne.de/record/284346
ER  -