000284347 001__ 284347
000284347 005__ 20260129113850.0
000284347 0247_ $$2doi$$a10.1021/jacs.5c19450
000284347 0247_ $$2pmid$$apmid:41552975
000284347 0247_ $$2ISSN$$a0002-7863
000284347 0247_ $$2ISSN$$a1520-5126
000284347 0247_ $$2ISSN$$a1943-2984
000284347 037__ $$aDZNE-2026-00118
000284347 041__ $$aEnglish
000284347 082__ $$a540
000284347 1001_ $$aWeil, Tatjana$$b0
000284347 245__ $$aAdvanced Molecular Tweezers Effectively Target Membranes Lacking Choline Headgroups for Broad-Spectrum Antiviral Efficacy.
000284347 260__ $$aWashington, DC$$bACS Publications$$c2026
000284347 3367_ $$2DRIVER$$aarticle
000284347 3367_ $$2DataCite$$aOutput Types/Journal article
000284347 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1769682956_4636
000284347 3367_ $$2BibTeX$$aARTICLE
000284347 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000284347 3367_ $$00$$2EndNote$$aJournal Article
000284347 520__ $$aBroad-spectrum antivirals are urgently required to counter present and emerging viral threats. It has previously been shown that the parental molecular tweezers CLR01 and CLR05 disrupt viral envelopes by complexing choline headgroups and that ester-functionalized 'advanced' tweezers display markedly enhanced antiviral potency. Here, we determine the molecular basis of this improved activity. Using liposome leakage assays, giant unilamellar vesicles, NMR, Langmuir film balance experiments, and atomistic simulations, we demonstrate that advanced tweezers not only encapsulate choline-containing lipids but also engage lipids lacking choline headgroups via transient and conserved hydrophobic insertion events. These interactions preferentially destabilize membranes enriched in sphingomyelin, unsaturated acyl chains, or inverted cone-shaped lipids and are especially effective against small, highly curved particles resembling viral particles, explaining their broad antiviral activity for enveloped viruses. Our findings reveal a dual mechanism of action, choline binding and hydrophobic insertion, that underpins the broad-spectrum antiviral activity of advanced molecular tweezers and establish them as a promising new class of membrane-targeting antivirals for prophylactic and therapeutic use.
000284347 536__ $$0G:(DE-HGF)POF4-351$$a351 - Brain Function (POF4-351)$$cPOF4-351$$fPOF IV$$x0
000284347 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000284347 7001_ $$00000-0003-3767-7130$$aLawrenz, Jan$$b1
000284347 7001_ $$aTaghuo Kaptouom, Estelle$$b2
000284347 7001_ $$00000-0002-7875-0886$$aMieres-Perez, Joel$$b3
000284347 7001_ $$0P:(DE-2719)9003513$$aHunszinger, Victoria$$b4$$udzne
000284347 7001_ $$0P:(DE-2719)9003481$$aSparrer, Konstantin M J$$b5
000284347 7001_ $$00000-0001-9832-3534$$aAlmeida-Hernandez, Yasser$$b6
000284347 7001_ $$00000-0002-7003-6362$$aSchrader, Thomas$$b7
000284347 7001_ $$00000-0002-9211-5803$$aSanchez-Garcia, Elsa$$b8
000284347 7001_ $$00000-0001-7316-7141$$aMünch, Jan$$b9
000284347 773__ $$0PERI:(DE-600)1472210-0$$a10.1021/jacs.5c19450$$gVol. 148, no. 3, p. 3626 - 3637$$n3$$p3626 - 3637$$tJournal of the American Chemical Society$$v148$$x0002-7863$$y2026
000284347 8564_ $$uhttps://pub.dzne.de/record/284347/files/DZNE-2026-00118_Restricted.pdf
000284347 8564_ $$uhttps://pub.dzne.de/record/284347/files/DZNE-2026-00118_SUPP.pdf
000284347 8564_ $$uhttps://pub.dzne.de/record/284347/files/DZNE-2026-00118_Restricted.pdf?subformat=pdfa$$xpdfa
000284347 8564_ $$uhttps://pub.dzne.de/record/284347/files/DZNE-2026-00118_SUPP.pdf?subformat=pdfa$$xpdfa
000284347 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9003513$$aExternal Institute$$b4$$kExtern
000284347 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9003481$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000284347 9131_ $$0G:(DE-HGF)POF4-351$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vBrain Function$$x0
000284347 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2024-12-13$$wger
000284347 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ AM CHEM SOC : 2022$$d2024-12-13
000284347 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-13
000284347 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-13
000284347 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2024-12-13
000284347 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2024-12-13
000284347 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-13
000284347 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2024-12-13
000284347 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-13
000284347 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-13
000284347 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2024-12-13
000284347 915__ $$0StatID:(DE-HGF)1200$$2StatID$$aDBCoverage$$bChemical Reactions$$d2024-12-13
000284347 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-13
000284347 915__ $$0StatID:(DE-HGF)1210$$2StatID$$aDBCoverage$$bIndex Chemicus$$d2024-12-13
000284347 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-13
000284347 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-13
000284347 915__ $$0StatID:(DE-HGF)9915$$2StatID$$aIF >= 15$$bJ AM CHEM SOC : 2022$$d2024-12-13
000284347 9201_ $$0I:(DE-2719)1910003$$kAG Sparrer$$lNeurovirology and Neuroinflammation$$x0
000284347 980__ $$ajournal
000284347 980__ $$aEDITORS
000284347 980__ $$aVDBINPRINT
000284347 980__ $$aI:(DE-2719)1910003
000284347 980__ $$aUNRESTRICTED