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000284356 1001_ $$0P:(DE-2719)9003609$$aWolff, Andreas$$b0$$udzne
000284356 245__ $$aRetrospective analysis of neurofilament-light chain in patients with inflammatory bowel disease – A pilot study
000284356 260__ $$aSan Francisco, California, US$$bPLOS$$c2026
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000284356 520__ $$aChronic inflammatory bowel diseases, encompassing Crohn's disease and ulcerative colitis, are characterized by persistent inflammation of the gastrointestinal tract. While traditionally regarded as confined to the gut, the systemic nature of inflammatory bowel disease has been increasingly recognized. The nervous system has garnered particular attention due to molecular and clinical evidence suggesting a potential interplay between inflammatory bowel disease and neurodegenerative diseases. Inflammatory bowel disease patients have a higher risk of developing neurological disorders such as Parkinson's disease, all-cause dementia, and multiple sclerosis. Still, causative molecular mechanisms are poorly understood. Neurofilament light chain (NfL) has been established as a disease-independent biomarker of axonal damage reflecting neurodegeneration.In this pilot study, we assessed molecular evidence of neurodegeneration by measuring serum NfL in a single-molecule array using the HD-X SIMOA platform (Quanterix, MA, USA) and employing correlation with clinical data in forty-nine patients with histopathologically confirmed inflammatory bowel disease. In total, 24 Crohn's disease patients, 25 ulcerative colitis patients, and 23 controls, aged 18-79 years, were included.We found an age-dependency of serological NfL levels, however, no apparent differences between disease groups and controls. Crohn's disease patients showed a slower age-dependent incline in serological NfL compared to control subjects (p = 0.03). No correlation of NfL with disease duration, disease severity, or inflammatory bowel disease treatment was found.A slower age-dependent increase in serological NfL levels was found in Crohn's disease patients compared to control subjects. Larger studies assessing additional markers of neurodegeneration may be instrumental in addressing this question in the future.
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000284356 650_7 $$2NLM Chemicals$$aNeurofilament Proteins
000284356 650_7 $$2NLM Chemicals$$aneurofilament protein L
000284356 650_7 $$2NLM Chemicals$$aBiomarkers
000284356 650_2 $$2MeSH$$aHumans
000284356 650_2 $$2MeSH$$aNeurofilament Proteins: blood
000284356 650_2 $$2MeSH$$aPilot Projects
000284356 650_2 $$2MeSH$$aAdult
000284356 650_2 $$2MeSH$$aMiddle Aged
000284356 650_2 $$2MeSH$$aMale
000284356 650_2 $$2MeSH$$aFemale
000284356 650_2 $$2MeSH$$aAged
000284356 650_2 $$2MeSH$$aBiomarkers: blood
000284356 650_2 $$2MeSH$$aAdolescent
000284356 650_2 $$2MeSH$$aYoung Adult
000284356 650_2 $$2MeSH$$aRetrospective Studies
000284356 650_2 $$2MeSH$$aInflammatory Bowel Diseases: blood
000284356 650_2 $$2MeSH$$aCrohn Disease: blood
000284356 650_2 $$2MeSH$$aCrohn Disease: pathology
000284356 650_2 $$2MeSH$$aColitis, Ulcerative: blood
000284356 650_2 $$2MeSH$$aColitis, Ulcerative: pathology
000284356 650_2 $$2MeSH$$aCase-Control Studies
000284356 7001_ $$aFeneberg, Emily$$b1
000284356 7001_ $$aShakhtour, Julius$$b2
000284356 7001_ $$00000-0002-7269-5433$$aSteiger, Katja$$b3
000284356 7001_ $$aSchmid, Roland M.$$b4
000284356 7001_ $$aHaller, Bernhard$$b5
000284356 7001_ $$aReinhardt, Nya$$b6
000284356 7001_ $$aMiddelhoff, Moritz$$b7
000284356 7001_ $$aSchult-Hannemann, David$$b8
000284356 7001_ $$0P:(DE-2719)2812561$$aLingor, Paul$$b9$$eLast author
000284356 773__ $$0PERI:(DE-600)2267670-3$$a10.1371/journal.pone.0340182$$gVol. 21, no. 1, p. e0340182 -$$n1$$pe0340182$$tPLOS ONE$$v21$$x1932-6203$$y2026
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