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@ARTICLE{Wolff:284356,
      author       = {Wolff, Andreas and Feneberg, Emily and Shakhtour, Julius
                      and Steiger, Katja and Schmid, Roland M. and Haller,
                      Bernhard and Reinhardt, Nya and Middelhoff, Moritz and
                      Schult-Hannemann, David and Lingor, Paul},
      title        = {{R}etrospective analysis of neurofilament-light chain in
                      patients with inflammatory bowel disease – {A} pilot
                      study},
      journal      = {PLOS ONE},
      volume       = {21},
      number       = {1},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {DZNE-2026-00124},
      pages        = {e0340182},
      year         = {2026},
      abstract     = {Chronic inflammatory bowel diseases, encompassing Crohn's
                      disease and ulcerative colitis, are characterized by
                      persistent inflammation of the gastrointestinal tract. While
                      traditionally regarded as confined to the gut, the systemic
                      nature of inflammatory bowel disease has been increasingly
                      recognized. The nervous system has garnered particular
                      attention due to molecular and clinical evidence suggesting
                      a potential interplay between inflammatory bowel disease and
                      neurodegenerative diseases. Inflammatory bowel disease
                      patients have a higher risk of developing neurological
                      disorders such as Parkinson's disease, all-cause dementia,
                      and multiple sclerosis. Still, causative molecular
                      mechanisms are poorly understood. Neurofilament light chain
                      (NfL) has been established as a disease-independent
                      biomarker of axonal damage reflecting neurodegeneration.In
                      this pilot study, we assessed molecular evidence of
                      neurodegeneration by measuring serum NfL in a
                      single-molecule array using the HD-X SIMOA platform
                      (Quanterix, MA, USA) and employing correlation with clinical
                      data in forty-nine patients with histopathologically
                      confirmed inflammatory bowel disease. In total, 24 Crohn's
                      disease patients, 25 ulcerative colitis patients, and 23
                      controls, aged 18-79 years, were included.We found an
                      age-dependency of serological NfL levels, however, no
                      apparent differences between disease groups and controls.
                      Crohn's disease patients showed a slower age-dependent
                      incline in serological NfL compared to control subjects (p =
                      0.03). No correlation of NfL with disease duration, disease
                      severity, or inflammatory bowel disease treatment was
                      found.A slower age-dependent increase in serological NfL
                      levels was found in Crohn's disease patients compared to
                      control subjects. Larger studies assessing additional
                      markers of neurodegeneration may be instrumental in
                      addressing this question in the future.},
      keywords     = {Humans / Neurofilament Proteins: blood / Pilot Projects /
                      Adult / Middle Aged / Male / Female / Aged / Biomarkers:
                      blood / Adolescent / Young Adult / Retrospective Studies /
                      Inflammatory Bowel Diseases: blood / Crohn Disease: blood /
                      Crohn Disease: pathology / Colitis, Ulcerative: blood /
                      Colitis, Ulcerative: pathology / Case-Control Studies /
                      Neurofilament Proteins (NLM Chemicals) / neurofilament
                      protein L (NLM Chemicals) / Biomarkers (NLM Chemicals)},
      cin          = {Clinical Research (Munich)},
      ddc          = {610},
      cid          = {I:(DE-2719)1111015},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1371/journal.pone.0340182},
      url          = {https://pub.dzne.de/record/284356},
}