000284360 001__ 284360
000284360 005__ 20260130151644.0
000284360 0247_ $$2doi$$a10.1038/s42003-025-09408-7
000284360 0247_ $$2pmid$$apmid:41455748
000284360 037__ $$aDZNE-2026-00128
000284360 041__ $$aEnglish
000284360 082__ $$a570
000284360 1001_ $$0P:(DE-2719)9002010$$aIliopoulos, Panagiotis$$b0$$eFirst author$$udzne
000284360 245__ $$aHippocampal-prefrontal connectivity relates to inter-individual differences and training gains in distinguishing similar memories.
000284360 260__ $$aLondon$$bSpringer Nature$$c2025
000284360 3367_ $$2DRIVER$$aarticle
000284360 3367_ $$2DataCite$$aOutput Types/Journal article
000284360 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1769782386_7594
000284360 3367_ $$2BibTeX$$aARTICLE
000284360 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000284360 3367_ $$00$$2EndNote$$aJournal Article
000284360 520__ $$aMnemonic discrimination (MD) is the ability to distinguish current experiences from similar memories. Research on the brain correlates of MD has focused on how regional neural responses are linked to MD. Here we go beyond this approach to investigate inter-regional functional connectivity patterns related to MD, its inter-individual variability and training-related improvement. Based on prior work we focused on medial temporal lobe (MTL), prefrontal cortex (PFC) and visual regions. We used fMRI to determine how connectivity patterns between these regions are related to MD before and after 2-weeks of web-based cognitive training. We found MD-related connectivity involving MTL-PFC-visual areas. Hippocampal-PFC connectivity was negatively associated with inter-individual variability in MD performance across two tasks. Hippocampal-PFC connectivity decrease was also linked to inter-individual variability in post-training MD improvement. Additionally, training led to increased connectivity from the lateral occipital cortex to the occipital pole area. Our results point to a hippocampal-PFC connectivity pattern that is a reliable marker of MD performance. This pattern is further related to MD training gains providing strong evidence for its role in distinguishing similar memories. Overall, we show that hippocampal-PFC connectivity constitutes a neural resource for MD that enables training-related improvement and may be targeted to enhance cognition.
000284360 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000284360 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000284360 650_2 $$2MeSH$$aHumans
000284360 650_2 $$2MeSH$$aHippocampus: physiology
000284360 650_2 $$2MeSH$$aHippocampus: diagnostic imaging
000284360 650_2 $$2MeSH$$aMale
000284360 650_2 $$2MeSH$$aFemale
000284360 650_2 $$2MeSH$$aPrefrontal Cortex: physiology
000284360 650_2 $$2MeSH$$aPrefrontal Cortex: diagnostic imaging
000284360 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000284360 650_2 $$2MeSH$$aAdult
000284360 650_2 $$2MeSH$$aYoung Adult
000284360 650_2 $$2MeSH$$aMemory: physiology
000284360 650_2 $$2MeSH$$aIndividuality
000284360 650_2 $$2MeSH$$aBrain Mapping
000284360 7001_ $$0P:(DE-2719)9001505$$aGüsten, Jeremie$$b1$$udzne
000284360 7001_ $$0P:(DE-2719)9001707$$aMhaolmhuaigh, Eoin$$b2$$udzne
000284360 7001_ $$00000-0003-4190-6071$$aCichy, Radoslaw Martin$$b3
000284360 7001_ $$0P:(DE-2719)9001743$$aKrohn, Friedrich$$b4$$udzne
000284360 7001_ $$0P:(DE-2719)2811815$$aMaass, Anne$$b5$$udzne
000284360 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b6$$eLast author$$udzne
000284360 773__ $$0PERI:(DE-600)2919698-X$$a10.1038/s42003-025-09408-7$$gVol. 9, no. 1, p. 129$$n1$$p129$$tCommunications biology$$v9$$x2399-3642$$y2025
000284360 8564_ $$uhttps://pub.dzne.de/record/284360/files/DZNE-2026-00128.pdf$$yRestricted
000284360 8564_ $$uhttps://pub.dzne.de/record/284360/files/DZNE-2026-00128.pdf?subformat=pdfa$$xpdfa$$yRestricted
000284360 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9002010$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000284360 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9001505$$aExternal Institute$$b1$$kExtern
000284360 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001707$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000284360 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001743$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000284360 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811815$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000284360 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000005$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000284360 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000284360 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCOMMUN BIOL : 2022$$d2024-12-11
000284360 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-11
000284360 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-11
000284360 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2024-04-10T15:36:12Z
000284360 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2024-04-10T15:36:12Z
000284360 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Anonymous peer review$$d2024-04-10T15:36:12Z
000284360 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2024-04-10T15:36:12Z
000284360 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2024-12-11
000284360 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2024-12-11
000284360 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-11
000284360 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2024-12-11
000284360 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-11
000284360 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-11
000284360 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2024-12-11
000284360 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-11
000284360 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-11
000284360 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-11
000284360 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bCOMMUN BIOL : 2022$$d2024-12-11
000284360 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2024-12-11
000284360 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2024-12-11
000284360 9201_ $$0I:(DE-2719)5000006$$kAG Düzel$$lClinical Neurophysiology and Memory$$x0
000284360 9201_ $$0I:(DE-2719)1311001$$kAG Maaß$$lMultimodal Neuroimaging$$x1
000284360 980__ $$ajournal
000284360 980__ $$aEDITORS
000284360 980__ $$aVDBINPRINT
000284360 980__ $$aI:(DE-2719)5000006
000284360 980__ $$aI:(DE-2719)1311001
000284360 980__ $$aUNRESTRICTED