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@ARTICLE{Iliopoulos:284360,
      author       = {Iliopoulos, Panagiotis and Güsten, Jeremie and
                      Mhaolmhuaigh, Eoin and Cichy, Radoslaw Martin and Krohn,
                      Friedrich and Maass, Anne and Düzel, Emrah},
      title        = {{H}ippocampal-prefrontal connectivity relates to
                      inter-individual differences and training gains in
                      distinguishing similar memories.},
      journal      = {Communications biology},
      volume       = {9},
      number       = {1},
      issn         = {2399-3642},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2026-00128},
      pages        = {129},
      year         = {2025},
      abstract     = {Mnemonic discrimination (MD) is the ability to distinguish
                      current experiences from similar memories. Research on the
                      brain correlates of MD has focused on how regional neural
                      responses are linked to MD. Here we go beyond this approach
                      to investigate inter-regional functional connectivity
                      patterns related to MD, its inter-individual variability and
                      training-related improvement. Based on prior work we focused
                      on medial temporal lobe (MTL), prefrontal cortex (PFC) and
                      visual regions. We used fMRI to determine how connectivity
                      patterns between these regions are related to MD before and
                      after 2-weeks of web-based cognitive training. We found
                      MD-related connectivity involving MTL-PFC-visual areas.
                      Hippocampal-PFC connectivity was negatively associated with
                      inter-individual variability in MD performance across two
                      tasks. Hippocampal-PFC connectivity decrease was also linked
                      to inter-individual variability in post-training MD
                      improvement. Additionally, training led to increased
                      connectivity from the lateral occipital cortex to the
                      occipital pole area. Our results point to a hippocampal-PFC
                      connectivity pattern that is a reliable marker of MD
                      performance. This pattern is further related to MD training
                      gains providing strong evidence for its role in
                      distinguishing similar memories. Overall, we show that
                      hippocampal-PFC connectivity constitutes a neural resource
                      for MD that enables training-related improvement and may be
                      targeted to enhance cognition.},
      keywords     = {Humans / Hippocampus: physiology / Hippocampus: diagnostic
                      imaging / Male / Female / Prefrontal Cortex: physiology /
                      Prefrontal Cortex: diagnostic imaging / Magnetic Resonance
                      Imaging / Adult / Young Adult / Memory: physiology /
                      Individuality / Brain Mapping},
      cin          = {AG Düzel / AG Maaß},
      ddc          = {570},
      cid          = {I:(DE-2719)5000006 / I:(DE-2719)1311001},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:41455748},
      doi          = {10.1038/s42003-025-09408-7},
      url          = {https://pub.dzne.de/record/284360},
}