%0 Journal Article
%A Abolhassani, Ayda
%A Alawathurage, T Madhusankha
%A Schmidt, Axel
%A Brand, Fabian
%A Kilarski, Laura L
%A Altmann, Heidi
%A Dahl, Edgar
%A Frank, Sandra
%A Göpel, Siri
%A Hanses, Frank
%A Hellmuth, Johannes Christian
%A Herr, Christian
%A Kaasch, Achim J
%A Kobbe, Robin
%A Konik, Margarethe Justine
%A Pink, Isabell
%A Römmele, Christoph
%A Rupp, Jan
%A Scheer, Christian S
%A Schneider, Marc A
%A Stellbrink, Christoph
%A Stubbe, Hans Christian
%A Tepasse, Phil-Robin
%A Teufel, Andreas
%A Vadász, István
%A Vehreschild, Maria J G T
%A Witzenrath, Martin
%A Anton, Gabriele
%A Bröhl, Isabel
%A Herold, Susanne
%A Illig, Thomas
%A Jiru-Hillmann, Steffi
%A Krawitz, Peter
%A Mitrov, Lazar
%A Philipsen, Alexandra
%A Pütz, Sina M
%A Noethen, Markus M
%A Nuernberg, Peter
%A Reese, Jens-Peter
%A Riess, Olaf
%A Schreiber, Stefan
%A Schultze, Joachim
%A Steinbeis, Fridolin
%A Vehreschild, J Janne
%A Wildberg, Christian
%A Ludwig, Kerstin U
%A Schulte, Eva C
%T Genetic contribution to severe COVID-19 in adults under 60 years without major comorbidities in the German National Pandemic Cohort Network (NAPKON).
%J Human genomics
%V 20
%N 1
%@ 1473-9542
%C London [u.a.]
%I Henry Stewart Publ.
%M DZNE-2026-00131
%P 23
%D 2026
%X While genome-wide association studies (GWAS) have linked common genetic variants to COVID-19 susceptibility and severity, rare high-impact variants may also contribute to phenotypic heterogeneity. Inborn errors of type I interferon immunity (IFN-I-IEIs), including X-linked TLR7 deficiency, account for   2
%K Humans
%K COVID-19: genetics
%K COVID-19: epidemiology
%K COVID-19: virology
%K Male
%K Female
%K Adult
%K Middle Aged
%K Germany: epidemiology
%K Genome-Wide Association Study
%K SARS-CoV-2
%K Genetic Predisposition to Disease
%K Toll-Like Receptor 7: genetics
%K Cohort Studies
%K Severity of Illness Index
%K Comorbidity
%K Pandemics
%K Gene Frequency
%K Interferon Type I: genetics
%K Multifactorial Inheritance
%K Polymorphism, Single Nucleotide
%K Toll-Like Receptor 7 (NLM Chemicals)
%K TLR7 protein, human (NLM Chemicals)
%K Interferon Type I (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:41578410
%2 pmc:PMC12849158
%R 10.1186/s40246-025-00904-9
%U https://pub.dzne.de/record/284363